Synthesis and Cytotoxic Activities of 2-(4-(2-heterocycloethoxy)phenyl)- 1,2,4-triazolo[1,5-a] Pyridines

Title: Synthesis and Cytotoxic Activities of 2-(4-(2-heterocycloethoxy)phenyl)- 1,2,4-triazolo[1,5-a] Pyridines

Volume: 8 Issue: 3

Author(s): Guolin Zhang and Jun Chen

Affiliation:

Keywords: Synthesis, cytotoxic, 1,2,4-triazolo[1,5-a] pyridines, benzyloxyphenyl, methyl, fungi, cycloethoxy, phenyl, ethyloxyphenyl, morpholino

Abstract: Nine 2-(4-(2-heterocycloethoxy)phenyl)-1,2,4-triazolo[1,5-a] pyridines have been synthesized. The structures of all products were confirmed by 1H NMR and HRMS. The cytotoxic activities of these compounds were evaluated against human ovary cancer cell line (HO-8910) in vitro by MTT method. The preliminary results showed that compound 4e (IC50 0.11mM) and compound 4f (IC50 0.11mM) exhibited moderate activity against the cancer cell line when compared with Cisplatin.

Cite this article as:

Zhang Guolin and Chen Jun, Synthesis and Cytotoxic Activities of 2-(4-(2-heterocycloethoxy)phenyl)- 1,2,4-triazolo[1,5-a] Pyridines, Letters in Organic Chemistry 2011; 8 (3) . https://dx.doi.org/10.2174/157017811795038377