Abstract
Guanine-rich DNA sequences can form planar four-stranded structures via Hoogsteen hydrogen bonds. These sequences in telomeric DNA and some oncogenes have been identified as targets for novel anticancer drugs. Consequently, there is great current interest in developing small molecules that can facilitate the formation of, and stabilize G-quadruplexes as potent antitumor chemotherapeutic agents. Metal complexes with planar geometries and π-delocalised ligands are emerging as a new class of quadruplex DNA ligand with unique features for optimal binding. This review will summarize the different types of metal-based compounds that target G-quadruplexes and provide useful information on the design of small ligands.
Keywords: G-quadruplexes, telomeric DNA, telomeres, targets, anticancer drug, metal complexes, ligand, stabilization
Mini-Reviews in Medicinal Chemistry
Title: Metallo-Organic G-Quadruplex Ligands in Anticancer Drug Design
Volume: 10 Issue: 8
Author(s): Y.-L. Jiang and Z.-P. Liu
Affiliation:
Keywords: G-quadruplexes, telomeric DNA, telomeres, targets, anticancer drug, metal complexes, ligand, stabilization
Abstract: Guanine-rich DNA sequences can form planar four-stranded structures via Hoogsteen hydrogen bonds. These sequences in telomeric DNA and some oncogenes have been identified as targets for novel anticancer drugs. Consequently, there is great current interest in developing small molecules that can facilitate the formation of, and stabilize G-quadruplexes as potent antitumor chemotherapeutic agents. Metal complexes with planar geometries and π-delocalised ligands are emerging as a new class of quadruplex DNA ligand with unique features for optimal binding. This review will summarize the different types of metal-based compounds that target G-quadruplexes and provide useful information on the design of small ligands.
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Cite this article as:
Jiang Y.-L. and Liu Z.-P., Metallo-Organic G-Quadruplex Ligands in Anticancer Drug Design, Mini-Reviews in Medicinal Chemistry 2010; 10 (8) . https://dx.doi.org/10.2174/138955710791572433
DOI https://dx.doi.org/10.2174/138955710791572433 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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