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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Cyclodextrins: More than Pharmaceutical Excipients

Author(s): F.J. Otero-Espinar, A. Luzardo-Alvarez and J. Blanco-Mendez

Volume 10, Issue 8, 2010

Page: [715 - 725] Pages: 11

DOI: 10.2174/138955710791572479

Price: $65

Abstract

Cyclodextrins are pharmaceutical excipients used to enhance the solubility, stability, safety and bioavailability of drugs. Recent findings have shown them to display adjuvant activity in vaccine therapy and prophylactic and therapeutic activity in the treatment of several host-pathogen infections. This article focuses on their activity and mechanism of action.

Keywords: Cyclodextrins, protein refolding, Bacillus anthracis, Cryptosporidium spp., Human Immunodeficiency Virus, immunomodulation, Leishmania spp., Plasmodium spp.


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