Synthesis, Characterization by Means of IR, 1H, 13C - NMR and Biological Investigations on New Diorganotin Carboxylic Acid Derivatives

Title: Synthesis, Characterization by Means of IR, 1H, 13C - NMR and Biological Investigations on New Diorganotin Carboxylic Acid Derivatives

Volume: 7 Issue: 7

Author(s): Abderrahmane Yahyi, Abdelkader Et-Touhami, Rachid Yahyaoui and Rachid Touzani

Affiliation:

Keywords: Synthesis, Tin, Carboxylic acids, Antitumor activities

Abstract: New organotin (IV) based on 2-(thiophene-2-yl)acetic acid and 1-H-pyrazole-3-carboxylic acid derivatives 1-ae and 2a-e was prepared and characterized by IR, 1H and 13C NMR spectroscopy. These reactions were carried out under refluxing conditions using CHCl3 / EtOH (3:1) as solvents and 2:1 / 1:1 acid / metal oxide rations. The tin products were recuperated with moderate and good yields (55-85%). The Compounds (1b, 1e and 2e) were screened for their antitumor activities against two human tumor cell lines: HeLa, an epithelial cell from a fatal cervical carcinoma and HEK293, an embryonic kidney tumor. All three materials show an activity in vitro against these cell lines.

Cite this article as:

Yahyi Abderrahmane, Et-Touhami Abdelkader, Yahyaoui Rachid and Touzani Rachid, Synthesis, Characterization by Means of IR, 1H, 13C - NMR and Biological Investigations on New Diorganotin Carboxylic Acid Derivatives, Letters in Drug Design & Discovery 2010; 7 (7) . https://dx.doi.org/10.2174/157018010791526241