Abstract
Kv1.5 channels are homotetramers of α-pore subunits mainly present in human atrium and pulmonary vasculature. Thus, Kv1.5 is a pharmacological target for cardiovascular diseases. Kvβ1.3 assemblies with Kvα1.5 and modifies its gating and pharmacology. A further knowledge of α-β interactions and pharmacology will lead a better design of new drugs.
Keywords: Ion channels, Kv channels, Beta subunits, Kvβ1.3, Kv1.5, Bupivacaine
Mini-Reviews in Medicinal Chemistry
Title: Kv1.5-Kvβ Interactions: Molecular Determinants and Pharmacological Consequences
Volume: 10 Issue: 7
Author(s): Teresa Gonzalez, Miren David, Cristina Moreno, Alvaro Macias and Carmen Valenzuela
Affiliation:
Keywords: Ion channels, Kv channels, Beta subunits, Kvβ1.3, Kv1.5, Bupivacaine
Abstract: Kv1.5 channels are homotetramers of α-pore subunits mainly present in human atrium and pulmonary vasculature. Thus, Kv1.5 is a pharmacological target for cardiovascular diseases. Kvβ1.3 assemblies with Kvα1.5 and modifies its gating and pharmacology. A further knowledge of α-β interactions and pharmacology will lead a better design of new drugs.
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Cite this article as:
Gonzalez Teresa, David Miren, Moreno Cristina, Macias Alvaro and Valenzuela Carmen, Kv1.5-Kvβ Interactions: Molecular Determinants and Pharmacological Consequences, Mini-Reviews in Medicinal Chemistry 2010; 10 (7) . https://dx.doi.org/10.2174/138955710791384018
DOI https://dx.doi.org/10.2174/138955710791384018 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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