Abstract
Tea (Camellia sinensis), a popular beverage, is consumed worldwide. The biological activities and mechanism( s) of chemopreventive effects of green tea polyphenols (monomeric catechins) have been extensively studied, while similar information regarding newly formed major black tea polyphenols (BTPs-oligomeric, polymeric) is not available. Therefore, this review focuses mainly on compiling the evidence on chemopreventive efficacy of black tea extract (BTE) / BTPs and describing their mechanism(s) of anti-initiating, anti-promoting and anti-progressor action(s) in in vivo experimental systems. Overall, the mechanism(s) implicated in the BTPs-mediated inhibition are diverse and involve effects on multiple molecular pathways and genes.
Keywords: Carcinogens, in vivo models, tumorigenesis, black tea polyphenols, chemoprevention, anti-initiation, anti-promotion, anti-progression
Mini-Reviews in Medicinal Chemistry
Title: Black Tea Polyphenols-Mediated In Vivo Cellular Responses During Carcinogenesis
Volume: 10 Issue: 6
Author(s): G. Kumar, S.P. Pillare and G.B. Maru
Affiliation:
Keywords: Carcinogens, in vivo models, tumorigenesis, black tea polyphenols, chemoprevention, anti-initiation, anti-promotion, anti-progression
Abstract: Tea (Camellia sinensis), a popular beverage, is consumed worldwide. The biological activities and mechanism( s) of chemopreventive effects of green tea polyphenols (monomeric catechins) have been extensively studied, while similar information regarding newly formed major black tea polyphenols (BTPs-oligomeric, polymeric) is not available. Therefore, this review focuses mainly on compiling the evidence on chemopreventive efficacy of black tea extract (BTE) / BTPs and describing their mechanism(s) of anti-initiating, anti-promoting and anti-progressor action(s) in in vivo experimental systems. Overall, the mechanism(s) implicated in the BTPs-mediated inhibition are diverse and involve effects on multiple molecular pathways and genes.
Export Options
About this article
Cite this article as:
Kumar G., Pillare S.P. and Maru G.B., Black Tea Polyphenols-Mediated In Vivo Cellular Responses During Carcinogenesis, Mini-Reviews in Medicinal Chemistry 2010; 10 (6) . https://dx.doi.org/10.2174/138955710791384063
DOI https://dx.doi.org/10.2174/138955710791384063 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Mitochondria as a Therapeutic Target in Metabolic Disorders
Mitochondria are the primary site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, these organelles are an important source of reactive oxygen and nitrogen species in virtually any nucleated cell type. The modulation of a myriad of cellular signaling pathways depends on the mitochondrial physiology. Mitochondrial dysfunction is observed ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Porphyrins as Radiosensitizing Agents for Solid Neoplasms
Current Pharmaceutical Design NF-κB1 Intronic Region Polymorphisms as Risk Factor for Head and Neck Cancer in HPV-Infected Population from Pakistan
Current Molecular Medicine LncRNA as a Therapeutic Target for Angiogenesis
Current Topics in Medicinal Chemistry Oral HPV Infection: Current Strategies for Prevention and Therapy
Current Pharmaceutical Design The Interaction of Histone Deacetylase Inhibitors and DNA Methyltransferase Inhibitors in the Treatment of Human Cancer Cells
Current Medicinal Chemistry - Anti-Cancer Agents Microarray Technology as a Universal Tool for High-Throughput Analysis of Biological Systems
Combinatorial Chemistry & High Throughput Screening OPLS-DA as a Suitable Method for Selecting a Set of Gene Transcripts Discriminating RAS- and PTPN11-Mutated Cells in Acute Lymphoblastic Leukaemia
Combinatorial Chemistry & High Throughput Screening EBV-Related Malignancies, Outcomes and Novel Prevention Strategies
Infectious Disorders - Drug Targets Cancer Stem Cells with Overexpression of Neuronal Markers Enhance Chemoresistance and Invasion in Retinoblastoma
Current Cancer Drug Targets Radiosensitizing Effect of Electrochemotherapy: A Systematic Review of Protocols and Efficiency
Current Drug Targets Imiquimod 5% Cream Use in Dermatology, Side Effects and Recent Patents
Recent Patents on Inflammation & Allergy Drug Discovery Drug Design Studies of the Novel Antitumor Targets Carbonic Anhydrase IX and XII
Current Medicinal Chemistry Restoration of Antitumor Immunity Through Selective Inhibition of Myeloid Derived Suppressor Cells by Anticancer Therapies
Current Molecular Medicine Maxillary Metastasis of Esophageal Cancer: Report of the First Case and Literature Review
Combinatorial Chemistry & High Throughput Screening Addressing the Challenge: Current and Future Directions in Ovarian Cancer Therapy
Current Gene Therapy Malignant Mesothelioma: Cell Survival Pathways and Radiation Therapy
Current Respiratory Medicine Reviews Evaluation of the Anticancer Activities of the Plant Alkaloids Sanguinarine and Chelerythrine in Human Breast Adenocarcinoma Cells
Anti-Cancer Agents in Medicinal Chemistry Progesterone Receptor Membrane Component 1 and its Accomplice: Emerging Therapeutic Targets in Lung Cancer
Endocrine, Metabolic & Immune Disorders - Drug Targets Morin Inhibits Ovarian Cancer Growth through the Inhibition of NF-κB Signaling Pathway
Anti-Cancer Agents in Medicinal Chemistry Long Non-coding RNA AFAP1-AS1 Facilitates Prostate Cancer Progression by Regulating miR-15b/IGF1R Axis
Current Pharmaceutical Design