Abstract
Development of the asymmetric [C+NC+CC] coupling reaction is described. This reaction assembles aldehyde (C), amine (NC), and alkene (CC) components in a predictable and controlled fashion to give highly functionalized pyrrolidines. The utility of the asymmetric [C+NC+CC] coupling reaction is demonstrated by its application to an efficient formal total synthesis of cyanocycline A.
Keywords: Asymmetric synthesis, azomethine ylide cycloaddition, cyanocycline A, multicomponent reaction, pyrrolidine synthesis
Current Organic Synthesis
Title: The Asymmetric [C+NC+CC] Coupling Reaction: Development and Application to Natural Product Synthesis
Volume: 7 Issue: 4
Author(s): P. Garner and H.U. Kaniskan
Affiliation:
Keywords: Asymmetric synthesis, azomethine ylide cycloaddition, cyanocycline A, multicomponent reaction, pyrrolidine synthesis
Abstract: Development of the asymmetric [C+NC+CC] coupling reaction is described. This reaction assembles aldehyde (C), amine (NC), and alkene (CC) components in a predictable and controlled fashion to give highly functionalized pyrrolidines. The utility of the asymmetric [C+NC+CC] coupling reaction is demonstrated by its application to an efficient formal total synthesis of cyanocycline A.
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Cite this article as:
Garner P. and Kaniskan H.U., The Asymmetric [C+NC+CC] Coupling Reaction: Development and Application to Natural Product Synthesis, Current Organic Synthesis 2010; 7 (4) . https://dx.doi.org/10.2174/157017910791414517
DOI https://dx.doi.org/10.2174/157017910791414517 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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