Abstract
Benzoquinones are class of natural quinones found chiefly in higher plants, fungi, bacteria and animal kingdom. They are involved in important biological functions such as bioenergetic transport, oxidative phosphorylation and electron transport processes. In recent years it has become increasingly clear that some of them possess potent antioxidant, anti-inflammatory and anticancer activities. There is clearly a common thread running through these activities and there have been a large number of studies carried out to unravel the mechanisms of these activities. In the present review we have provided a brief account of these studies especially covering these aspects. Although antioxidant potentials of these compounds constitute the basis of their biological activities its nature and scope is dictated by many microscopic biological environments. One of the important advantages offered by these compounds is the ease with which they can be synthesized and chemically manipulated. This can easily provide impetus for further research in developing some potentially useful drug molecules.
Keywords: Anticancer, anti-inflammatory, antioxidant, benzoquinone, benzoquinone analogs, quinone
Mini-Reviews in Medicinal Chemistry
Title: Perspectives on Medicinal Properties of Benzoquinone Compounds
Volume: 10 Issue: 5
Author(s): P.R. Dandawate, A.C. Vyas, S.B. Padhye, M.W. Singh and J.B. Baruah
Affiliation:
Keywords: Anticancer, anti-inflammatory, antioxidant, benzoquinone, benzoquinone analogs, quinone
Abstract: Benzoquinones are class of natural quinones found chiefly in higher plants, fungi, bacteria and animal kingdom. They are involved in important biological functions such as bioenergetic transport, oxidative phosphorylation and electron transport processes. In recent years it has become increasingly clear that some of them possess potent antioxidant, anti-inflammatory and anticancer activities. There is clearly a common thread running through these activities and there have been a large number of studies carried out to unravel the mechanisms of these activities. In the present review we have provided a brief account of these studies especially covering these aspects. Although antioxidant potentials of these compounds constitute the basis of their biological activities its nature and scope is dictated by many microscopic biological environments. One of the important advantages offered by these compounds is the ease with which they can be synthesized and chemically manipulated. This can easily provide impetus for further research in developing some potentially useful drug molecules.
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Dandawate P.R., Vyas A.C., Padhye S.B., Singh M.W. and Baruah J.B., Perspectives on Medicinal Properties of Benzoquinone Compounds, Mini-Reviews in Medicinal Chemistry 2010; 10 (5) . https://dx.doi.org/10.2174/138955710791330909
DOI https://dx.doi.org/10.2174/138955710791330909 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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