N-(tert)-Butyloxycarbonyl-β,β-Cyclopentyl-Cysteine (Acetamidomethyl)-Methyl Ester for Synthesis of Novel Peptidomimetic Derivatives

Title: N-(tert)-Butyloxycarbonyl-β,β-Cyclopentyl-Cysteine (Acetamidomethyl)-Methyl Ester for Synthesis of Novel Peptidomimetic Derivatives

Volume: 17 Issue: 7

Author(s): Adriano Mollica, Federica Feliciani, Azzurra Stefanucci, Ivana Cacciatore, Catia Cornacchia, Domenica Torino and Francesco Pinnen

Affiliation:

Keywords: Peptides, peptidomimetic, cysteine, thiols, β,β—dialkyl-amino acids, χ-space

Abstract: It has been recently reported that thiol groups could play an important role in the protection of neuronal cells in Alzheimers disease (AD), prion disease (CJD) and Parkinsons disease (PD). Also bucillamine, that is a pseudo dipeptide possessing a thiol group capable to form an internal disulfide bridge, has relevant scavenger properties used in therapy for the treatment of arthritis. Furthermore, many sulphur containing compounds show strong chelating properties to heavy metals. Due to the crucial role of thiol groups in a variety of detoxicant biological systems, we report the synthesis of a racemic β,β-dialkyl-substituted, fully protected, cysteine derivative as a suitable intermediate in the synthesis of novel biological active peptides.

Cite this article as:

Mollica Adriano, Feliciani Federica, Stefanucci Azzurra, Cacciatore Ivana, Cornacchia Catia, Torino Domenica and Pinnen Francesco, N-(tert)-Butyloxycarbonyl-β,β-Cyclopentyl-Cysteine (Acetamidomethyl)-Methyl Ester for Synthesis of Novel Peptidomimetic Derivatives, Protein & Peptide Letters 2010; 17 (7) . https://dx.doi.org/10.2174/092986610791306760