Esters of Dehydroepiandrosterone (DHEA) as Probes for the Active Site of Type 3 17β-Hydroxysteroid Dehydrogenase (17β-HSD3)

Title: Esters of Dehydroepiandrosterone (DHEA) as Probes for the Active Site of Type 3 17β-Hydroxysteroid Dehydrogenase (17β-HSD3)

Volume: 7 Issue: 5

Author(s): Moniola S. Olusanjo, Caroline P. Owen and Sabbir Ahmed

Affiliation:

Keywords: 17β-hydroxysteroid dehydrogenase, Type 3, Inhibition, Enzyme, Steroid-based compound

Abstract: We report the use of steroid-based compounds as probes for the active site of 17β-hydroxysteroid dehydrogenase, in particular, type 3 (17β-HSD3). Results suggest that the compounds were good inhibitors of 17β-HSD3 – a number were extremely potent with respect to the standard compounds used.

Cite this article as:

S. Olusanjo Moniola, P. Owen Caroline and Ahmed Sabbir, Esters of Dehydroepiandrosterone (DHEA) as Probes for the Active Site of Type 3 17β-Hydroxysteroid Dehydrogenase (17β-HSD3), Letters in Drug Design & Discovery 2010; 7 (5) . https://dx.doi.org/10.2174/157018010791163505