Abstract
Synthesis and analgesic activity studies of a series of L-amino acid based compounds were described. These compounds were designed as potential N-type Calcium Channel Blockers and their structures were confirmed by 1H NMR and ESI-MS spectra. Some of the compounds exhibited significant analgesic activity in Mouse Hot-Plate tests. According to the data of pharmacological experiments, we carried out preliminary structure-activity studies and the results indicated that this kind of compounds was useful for the development of new analgesic drugs.
Keywords: Analgesic, Calcium antagonist, Synthesis, Hot-plate test, L-amino acid
Letters in Drug Design & Discovery
Title: Synthesis and Biological Activity of Novel L-Amino Acid Based Analgesic Compounds
Volume: 7 Issue: 5
Author(s): Junzhu Pan, Qianqian Wang, Gu He, Liang Ouyang and Li Guo
Affiliation:
Keywords: Analgesic, Calcium antagonist, Synthesis, Hot-plate test, L-amino acid
Abstract: Synthesis and analgesic activity studies of a series of L-amino acid based compounds were described. These compounds were designed as potential N-type Calcium Channel Blockers and their structures were confirmed by 1H NMR and ESI-MS spectra. Some of the compounds exhibited significant analgesic activity in Mouse Hot-Plate tests. According to the data of pharmacological experiments, we carried out preliminary structure-activity studies and the results indicated that this kind of compounds was useful for the development of new analgesic drugs.
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Cite this article as:
Pan Junzhu, Wang Qianqian, He Gu, Ouyang Liang and Guo Li, Synthesis and Biological Activity of Novel L-Amino Acid Based Analgesic Compounds, Letters in Drug Design & Discovery 2010; 7 (5) . https://dx.doi.org/10.2174/157018010791163497
DOI https://dx.doi.org/10.2174/157018010791163497 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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