Abstract
This article reviews the medicinal implications of 5-HT4R in the peripheral and central nervous systems, based on data from two hundred bibliographic references. An exhaustive compilation of molecules reported to be antagonists or agonists for 5-HT4R is presented, including chemical structures, binding properties and pharmacological profiles. In the last part of the review, some key concepts concerning structure-activity relationships are highlighted.
Keywords: Serotonin, 5-HT4 receptor ligands, Agonists, Antagonists, Clinical applications
Current Topics in Medicinal Chemistry
Title: Review of 5-HT4R Ligands: State of Art and Clinical Applications
Volume: 10 Issue: 5
Author(s): Ronan Bureau, Michel Boulouard, Francois Dauphin, Frank Lezoualc'h and Sylvain Rault
Affiliation:
Keywords: Serotonin, 5-HT4 receptor ligands, Agonists, Antagonists, Clinical applications
Abstract: This article reviews the medicinal implications of 5-HT4R in the peripheral and central nervous systems, based on data from two hundred bibliographic references. An exhaustive compilation of molecules reported to be antagonists or agonists for 5-HT4R is presented, including chemical structures, binding properties and pharmacological profiles. In the last part of the review, some key concepts concerning structure-activity relationships are highlighted.
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Cite this article as:
Bureau Ronan, Boulouard Michel, Dauphin Francois, Lezoualc'h Frank and Rault Sylvain, Review of 5-HT4R Ligands: State of Art and Clinical Applications, Current Topics in Medicinal Chemistry 2010; 10 (5) . https://dx.doi.org/10.2174/156802610791111551
DOI https://dx.doi.org/10.2174/156802610791111551 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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