Abstract
A series of seventeen disubstituted N-acylhydrazone pyrazinecarbohydrazide (4-20) have been synthesized and evaluated for their cell viabilities, were compared to another monosubstituted derivatives previously synthesized by us. This study indicated that the position and nature of the substituents in the aromatic ring influence the cytotoxicity of this series.
Keywords: Pyrazine, N-acylhydrazones, Tuberculosis, Drugs
Letters in Drug Design & Discovery
Title: Synthesis and Cytotoxic Evaluation of Disubstituted N-Acylhydrazones Pyrazinecarbohydrazide Derivatives
Volume: 7 Issue: 4
Author(s): Marcelle de L. Ferreira, Andre L.P. Candea, Maria das Gracas M. de O. Henriques, Carlos R. Kaiser, Camilo H. da S. Lima and Marcus V.N. de Souza
Affiliation:
Keywords: Pyrazine, N-acylhydrazones, Tuberculosis, Drugs
Abstract: A series of seventeen disubstituted N-acylhydrazone pyrazinecarbohydrazide (4-20) have been synthesized and evaluated for their cell viabilities, were compared to another monosubstituted derivatives previously synthesized by us. This study indicated that the position and nature of the substituents in the aromatic ring influence the cytotoxicity of this series.
Export Options
About this article
Cite this article as:
de L. Ferreira Marcelle, Candea L.P. Andre, de O. Henriques M. Maria das Gracas, Kaiser R. Carlos, da S. Lima H. Camilo and de Souza V.N. Marcus, Synthesis and Cytotoxic Evaluation of Disubstituted N-Acylhydrazones Pyrazinecarbohydrazide Derivatives, Letters in Drug Design & Discovery 2010; 7 (4) . https://dx.doi.org/10.2174/157018010790945814
DOI https://dx.doi.org/10.2174/157018010790945814 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Beneficial Role of Vitamin D in Human Immunodeficiency Virus Infection
Current HIV Research Differential Gene Expression of <i>ASUN, NEMF, PTPRC</i> and <i>DHX29</i>: Candidate Biomarkers for the Diagnosis of Active and Latent Tuberculosis
Infectious Disorders - Drug Targets An Unprecedented Revolution in Medicinal Chemistry Driven by the Progress of Biological Science
Current Topics in Medicinal Chemistry Social Leverage of Intellectual Property: Road to the Development of Better Therapy for Tuberculosis
Recent Patents on Anti-Infective Drug Discovery Epidemiology of Gout: Perspectives from the Past
Current Rheumatology Reviews Antimicrobial Precious-Metal Nanoparticles and their Use in Novel Materials
Recent Patents on Food, Nutrition & Agriculture The Effects of Obesity on Drug Metabolism in Children
Drug Metabolism Letters Peptide Arrays for the Analysis of Antibody Epitope Recognition Patterns
Mini-Reviews in Organic Chemistry Machine Learning and Tubercular Drug Target Recognition
Current Pharmaceutical Design DNA-Minor Groove Binding Agents as Anti-Tubercular Probes. Old Tools for a New Challenge?
Anti-Infective Agents Structure and Function of MPN (Mpr1/Pad1 N-terminal) Domain- Containing Proteins
Current Protein & Peptide Science Pharmacometrics in Dose Finding or Dose Optimization of Anti-Retroviral and Anti-Tubercular Drugs
Infectious Disorders - Drug Targets Inflammation in Fish As Seen from A Morphological Point of View with Special Reference to the Vascular Compartment
Current Pharmaceutical Design Antimycobacterial Agents: Synthesis and Biological Evaluation of Novel 4-(Substituted-phenyl)-6-methyl-2-oxo-N-(pyridin-2-yl)-1,2,3,4-tetrahydropyrimidine- 5-carboxamide Derivatives by Using One-pot Multicomponent Method
Letters in Drug Design & Discovery Recent Development and Future Perspective of Antitubercular Therapy
Anti-Infective Agents in Medicinal Chemistry Activation of Macrophages: Establishing a Role for Polysaccharides in Drug Delivery Strategies Envisaging Antibacterial Therapy
Current Pharmaceutical Design Programs to Facilitate Tuberculosis Drug Discovery: The Tuberculosis Antimicrobial Acquisition and Coordinating Facility
Infectious Disorders - Drug Targets Glycosyltransferases, Important Tools for Drug Design
Current Topics in Medicinal Chemistry Advances in Metabonomics on Infectious Diseases
Current Metabolomics The Role of Macrophages in Rheumatoid Arthritis
Current Pharmaceutical Design