Abstract
A series of novel fluoroaminophosphates 4a-4j were synthesized by one-pot method in presence of tetramethylguanidine (TMG) as a catalyst and were characterized by elemental analysis, FTIR, 1H, 13C, 31P, 19F NMR, and mass spectra. All the title compounds were evaluated for in vitro cytotoxicity against leukemic cell line derived from Tcells of leukemia patient (CEM cells) by Trypan blue exclusion and MTT assays, and these were found to exert concentration dependent cytotoxic effects. Among them 4f, 4g & 4j possessed marked cytotoxicity. 4g (with IC50 value of 6 iM) had emerged as lead compound.
Keywords: Aminophosphonate, Fluorine, TMG, Synthesis, Leukmia, CEM cell, Cytotoxicity
Letters in Drug Design & Discovery
Title: Synthesis, Characterization and Evaluation of Cytotoxicity of New Aminophosphonic Acid Diesters in Human Leukemia Cells
Volume: 7 Issue: 4
Author(s): Avula Balakrishna, Kishore K. Chiruvella, Mudumala V.N. Reddy, Rajesh Reddy, Sandip K. Nayak, Sathees C. Raghavan and Cirandur S. Reddy
Affiliation:
Keywords: Aminophosphonate, Fluorine, TMG, Synthesis, Leukmia, CEM cell, Cytotoxicity
Abstract: A series of novel fluoroaminophosphates 4a-4j were synthesized by one-pot method in presence of tetramethylguanidine (TMG) as a catalyst and were characterized by elemental analysis, FTIR, 1H, 13C, 31P, 19F NMR, and mass spectra. All the title compounds were evaluated for in vitro cytotoxicity against leukemic cell line derived from Tcells of leukemia patient (CEM cells) by Trypan blue exclusion and MTT assays, and these were found to exert concentration dependent cytotoxic effects. Among them 4f, 4g & 4j possessed marked cytotoxicity. 4g (with IC50 value of 6 iM) had emerged as lead compound.
Export Options
About this article
Cite this article as:
Balakrishna Avula, Chiruvella K. Kishore, Reddy V.N. Mudumala, Reddy Rajesh, Nayak K. Sandip, Raghavan C. Sathees and Reddy S. Cirandur, Synthesis, Characterization and Evaluation of Cytotoxicity of New Aminophosphonic Acid Diesters in Human Leukemia Cells, Letters in Drug Design & Discovery 2010; 7 (4) . https://dx.doi.org/10.2174/157018010790945841
DOI https://dx.doi.org/10.2174/157018010790945841 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Human Leukemia and Lymphoma Cell Lines as Models and Resources
Current Medicinal Chemistry Immunogenic Issues Concerning Recombinant Adeno-Associated Virus Vectors for Gene Therapy
Current Gene Therapy Domperidone and Long QT Syndrome
Current Drug Safety Biomarkers of Protein Oxidation in Human Disease
Current Molecular Medicine Ras Dimer Formation as a New Signaling Mechanism and Potential Cancer Therapeutic Target
Mini-Reviews in Medicinal Chemistry Chronic Eosinophilic Leukemia, Not Otherwise Specified (CEL, NOS)
Current Cancer Therapy Reviews Targeting Aurora Kinases in Cancer Treatment
Current Drug Targets Application of Mesenchymal Stem Cells in Melanoma: A Potential Therapeutic Strategy for Delivery of Targeted Agents
Current Medicinal Chemistry Critical Roles of EGFR Family Members in Breast Cancer and Breast Cancer Stem Cells: Targets for Therapy
Current Pharmaceutical Design Monoclonal Antobodies: Application in Radiopharmacy
Current Radiopharmaceuticals Clinical Pharmacology of Cyclophosphamide and Ifosfamide
Current Drug Therapy Inhibiting Breast Cancer Progression by Exploiting TGFβ Signaling
Current Drug Targets The ATP-driven Hsp60 Machinery: Biological and Clinical Implications
Current Immunology Reviews (Discontinued) Transmembrane Phosphatases and Cancer Development, the Role of Protein Tyrosine Phosphatase-kappa (PTPκ) and Protein Tyrosine Phosphatase-mu (PTPμ)
Current Signal Transduction Therapy A Practical Approach to Diagnosis and Treatment of Symptomatic Thromboembolic Events in Children with Acute Lymphoblastic Leukemia: Recommendations of the “Coagulation Defects” AIEOP Working Group
Recent Patents on Cardiovascular Drug Discovery In Vitro and In Vivo Experimental Model-based Approaches for Investigating Anti-inflammatory Properties of Coumarins
Current Medicinal Chemistry Acute and Sub-chronic Toxicity Analyses of Hot-Water Extract of Isaria japonica from Silkworm (Bombyx mori) Pupae
Current Traditional Medicine Opportunities and Challenges for Host-Directed Therapies in Tuberculosis
Current Pharmaceutical Design Anti-Gene Strategies to Down-Regulate Gene Expression in Mammalian Cells
Current Pharmaceutical Design Kavalactone Pharmacophores for Major Cellular Drug Targets
Mini-Reviews in Medicinal Chemistry