Abstract
Protein transduction therapy is a promising alternative to gene therapy, but has not previously been investigated for osteosarcoma. We here demonstrate efficient growth inhibition of human osteosarcoma cells using a p53 peptide. Our result suggests that protein transduction therapy has significant potential as a novel therapeutic approach for osteosarcoma.
Keywords: Osteosarcoma, p53 peptide, protein transduction therapy, protein transduction domain, poly arginine, nuclear localization signal
Protein & Peptide Letters
Title: Efficient Growth Inhibition of Human Osteosarcoma Cells Using a Peptide Derived from the MDM-2-Binding Site of p53
Volume: 17 Issue: 5
Author(s): R. Ito, H. Kanno, A. Takahashi, R. Matsumoto, N. Kobayashi, T. Yoshida and T. Saito
Affiliation:
Keywords: Osteosarcoma, p53 peptide, protein transduction therapy, protein transduction domain, poly arginine, nuclear localization signal
Abstract: Protein transduction therapy is a promising alternative to gene therapy, but has not previously been investigated for osteosarcoma. We here demonstrate efficient growth inhibition of human osteosarcoma cells using a p53 peptide. Our result suggests that protein transduction therapy has significant potential as a novel therapeutic approach for osteosarcoma.
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Cite this article as:
Ito R., Kanno H., Takahashi A., Matsumoto R., Kobayashi N., Yoshida T. and Saito T., Efficient Growth Inhibition of Human Osteosarcoma Cells Using a Peptide Derived from the MDM-2-Binding Site of p53, Protein & Peptide Letters 2010; 17 (5) . https://dx.doi.org/10.2174/092986610791112639
DOI https://dx.doi.org/10.2174/092986610791112639 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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