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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Efficient Growth Inhibition of Human Osteosarcoma Cells Using a Peptide Derived from the MDM-2-Binding Site of p53

Author(s): R. Ito, H. Kanno, A. Takahashi, R. Matsumoto, N. Kobayashi, T. Yoshida and T. Saito

Volume 17, Issue 5, 2010

Page: [610 - 615] Pages: 6

DOI: 10.2174/092986610791112639

Price: $65

Abstract

Protein transduction therapy is a promising alternative to gene therapy, but has not previously been investigated for osteosarcoma. We here demonstrate efficient growth inhibition of human osteosarcoma cells using a p53 peptide. Our result suggests that protein transduction therapy has significant potential as a novel therapeutic approach for osteosarcoma.

Keywords: Osteosarcoma, p53 peptide, protein transduction therapy, protein transduction domain, poly arginine, nuclear localization signal


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