Abstract
The synthesis of a series of andrographolide derivatives was described and their inhibitory effects on COX-2 expression in mouse macrophages were also evaluated. Some of the tested compounds showed better inhibitory potency than andrographolide, and compound (5d) was the best one.
Keywords: Andrographolide, Derivatives, COX-2, Expression, Inhibitory activity
Letters in Drug Design & Discovery
Title: Synthesis and Preliminary COX-2 Expression Inhibitory Activities of Andrographolide Derivatives
Volume: 7 Issue: 3
Author(s): Jing Li, Wenlong Huang, Huibin Zhang and Huiping Zhou
Affiliation:
Keywords: Andrographolide, Derivatives, COX-2, Expression, Inhibitory activity
Abstract: The synthesis of a series of andrographolide derivatives was described and their inhibitory effects on COX-2 expression in mouse macrophages were also evaluated. Some of the tested compounds showed better inhibitory potency than andrographolide, and compound (5d) was the best one.
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Cite this article as:
Li Jing, Huang Wenlong, Zhang Huibin and Zhou Huiping, Synthesis and Preliminary COX-2 Expression Inhibitory Activities of Andrographolide Derivatives, Letters in Drug Design & Discovery 2010; 7 (3) . https://dx.doi.org/10.2174/157018010790596614
DOI https://dx.doi.org/10.2174/157018010790596614 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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