Abstract
Some pentapeptides with higher alpha-helical tendency possess typical sequence pattern, such as “+ - + + - - +”, “+ - - + - - +”, “+ - + - - - +”, and “- + + - - - +” (“+” = D,N,E,Q,K,R,T,C, or H; “-” = L,I,V, or A), especially symmetrical motifs (a pair of reverse sequences beside palindromic segments), such as ALALA, QQAQE/EQAQQ, and REALE/ELAER, hint that the nascent peptide can fold a certain conformation in a two-way folding fashion.
Keywords: Folding models, symmetrical motifs, molecular dynamics
Protein & Peptide Letters
Title: Molecular Dynamics of Some Pentapeptides Having a Strong Tendency to Helical Conformation
Volume: 17 Issue: 3
Author(s): Zhuo-Ran Huang, Tong-Yang Zhu, Ting-Ting Wang, Xiao-Ning Wang and Jie Yang
Affiliation:
Keywords: Folding models, symmetrical motifs, molecular dynamics
Abstract: Some pentapeptides with higher alpha-helical tendency possess typical sequence pattern, such as “+ - + + - - +”, “+ - - + - - +”, “+ - + - - - +”, and “- + + - - - +” (“+” = D,N,E,Q,K,R,T,C, or H; “-” = L,I,V, or A), especially symmetrical motifs (a pair of reverse sequences beside palindromic segments), such as ALALA, QQAQE/EQAQQ, and REALE/ELAER, hint that the nascent peptide can fold a certain conformation in a two-way folding fashion.
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Cite this article as:
Huang Zhuo-Ran, Zhu Tong-Yang, Wang Ting-Ting, Wang Xiao-Ning and Yang Jie, Molecular Dynamics of Some Pentapeptides Having a Strong Tendency to Helical Conformation, Protein & Peptide Letters 2010; 17 (3) . https://dx.doi.org/10.2174/092986610790780369
DOI https://dx.doi.org/10.2174/092986610790780369 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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