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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

A Novel Approach to Predict Protein-Protein Interactions Related to Alzheimers Disease Based on Complex Network

Author(s): Jie Yang and Xiong-Fei Jiang

Volume 17, Issue 3, 2010

Page: [356 - 366] Pages: 11

DOI: 10.2174/092986610790780323

Price: $65

Abstract

A protein domain interaction prediction program was complied using C++ to predict whether a query protein could interact with other hub proteins. It is indicated that the proteins interacting with AATF (Apoptosis-Antagonizing Transcription Factor) possess a common conservative pattern: I-x(0,1)-E-x(2)-[A/E/N/T]-x-[E/K]. Our method is attempted to integrate the characteristics of protein interaction network with the simplest building blocks-conservative patterns.

Keywords: AD associated protein interaction network, signal pathway, conservative interaction pattern


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