Bryothamnion seaforthii Lectin Relaxes Vascular Smooth Muscle: Involvement of Endothelium and NO Synthase

Title: Bryothamnion seaforthii Lectin Relaxes Vascular Smooth Muscle: Involvement of Endothelium and NO Synthase

Volume: 17 Issue: 3

Author(s): Ricardo F. Lima, David N. Criddle, Pedro Marcos G. Soares, Samile Pereira Ribeiro, Benildo S. Cavada, Kyria S. Nascimento, Alexandre H. Sampaio and Ana Maria S. Assreuy

Affiliation:

Keywords: Lectin, agglutinin, Bryothamnion seaforthii, nitric oxide synthase, red marine alga

Abstract: Bryothamnion seaforthii lectin (BSL) induced reversible concentration-related relaxation of endothelized aorta, maximal at 30μg/ml (IC50= 4.8 ± 0.6μg/ml). This effect was inhibited by L-NAME and reversed by mucin, probably via interaction with a specific lectin-binding site on the endothelium activating nitric oxide synthase.

Cite this article as:

Lima F. Ricardo, Criddle N. David, Soares G. Pedro Marcos, Ribeiro Pereira Samile, Cavada S. Benildo, Nascimento S. Kyria, Sampaio H. Alexandre and Assreuy S. Ana Maria, Bryothamnion seaforthii Lectin Relaxes Vascular Smooth Muscle: Involvement of Endothelium and NO Synthase, Protein & Peptide Letters 2010; 17 (3) . https://dx.doi.org/10.2174/092986610790780332