Abstract
Synthesis and evaluation of C-28 oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase have been described. The results of glycogen phosphorylase inhibition assay and structure-activity relationship (SAR) analysis are also discussed.
Keywords: Glycogen phosphorylase, Oleanolic acid, C-28 derivatives, Synthesis, Inhibition
Letters in Drug Design & Discovery
Title: Synthesis and Evaluation of C-28 Oleanolic Acid Derivatives as Inhibitors of Glycogen Phosphorylase
Volume: 7 Issue: 2
Author(s): Keguang Cheng, Chao Wang, Jun Liu, Juan Xie and Hongbin Sun
Affiliation:
Keywords: Glycogen phosphorylase, Oleanolic acid, C-28 derivatives, Synthesis, Inhibition
Abstract: Synthesis and evaluation of C-28 oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase have been described. The results of glycogen phosphorylase inhibition assay and structure-activity relationship (SAR) analysis are also discussed.
Export Options
About this article
Cite this article as:
Cheng Keguang, Wang Chao, Liu Jun, Xie Juan and Sun Hongbin, Synthesis and Evaluation of C-28 Oleanolic Acid Derivatives as Inhibitors of Glycogen Phosphorylase, Letters in Drug Design & Discovery 2010; 7 (2) . https://dx.doi.org/10.2174/157018010790225921
DOI https://dx.doi.org/10.2174/157018010790225921 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Graphical Abstracts
Medicinal Chemistry Pharmacophore Development and SAR Studies of Imidazoline Receptor Ligands
Mini-Reviews in Medicinal Chemistry In Silico Modeling of P450 Substrates, Inhibitors, Activators, and Inducers
Combinatorial Chemistry & High Throughput Screening AMPK Activators as Novel Therapeutics for Type 2 Diabetes
Current Topics in Medicinal Chemistry Application of 3D-QSAR Techniques in Anti-HIV-1 Drug Design - An Overview
Current Pharmaceutical Design Targeting Kinin Receptors for the Treatment of Neurological Diseases
Current Pharmaceutical Design Arylsulfonylhydrazone Induced Apoptosis in MDA-MB-231 Breast Cancer Cells
Letters in Drug Design & Discovery La(NO<sub>3</sub>)<sub>3</sub>.6H<sub>2</sub>O Catalyzed One-pot Highly Diastereoselective Synthesis of Functionalized Piperidines
Letters in Organic Chemistry Modulation of Toll-Like Receptor 4. Insights from X-Ray Crystallography and Molecular Modeling
Current Topics in Medicinal Chemistry Designing Peptide Mimetics for the Treatment of Multiple Sclerosis
Mini-Reviews in Medicinal Chemistry Vanilloid Receptor Antagonists: Emerging Class of Novel Anti-Inflammatory Agents for Pain Management
Current Pharmaceutical Design Discovery, Structural Determination and Anticancer Activities of Lactucinlike Guaianolides
Letters in Drug Design & Discovery Giardiasis: Recent Progress in Chemotherapy and Drug Development (Hot Topic: Anti-Infective Agents Executive Editors: Mitchell A. Avery / Vassil St.) Georgiev
Current Pharmaceutical Design Targeting RAS Signaling Pathways in Juvenile Myelomonocytic Leukemia
Current Drug Targets An Overview on COVID-19: Clinical Features, Treatment and Prevention
Coronaviruses Recent Progress in the Development of Subtype Selective Nicotinic Acetylcholine Receptor Ligands
Current Drug Targets - CNS & Neurological Disorders It is Not Always COVID-19: Case Report about an Undiagnosed HIV Man with Dyspnea
Current HIV Research Activation of Intrinsic Apoptosis and G1 Cell Cycle Arrest by a Triazole Precursor, N-(4-chlorophenyl)-2-(4-(3,4,5-trimethoxybenzyloxy)benzoyl)-hydrazinecarbothioamide in Breast Cancer Cell Line
Anti-Cancer Agents in Medicinal Chemistry Neuropeptide Y1 and Y5 Receptor Antagonists as Potential Anti-Obesity Drugs: Current Status
Mini-Reviews in Medicinal Chemistry COVID-19: The Significance of Platelets, Mitochondria, Vitamin D, Serotonin and the Gut Microbiota
Current Medicinal Chemistry