Abstract
Pyrrolo[1,4]benzodiazepines (PBDs) are a growing group of microbial secondary metabolites that showed remarkable biological activities particularly against tumor cells. Their antitumor activity is mainly due to their specifically binding to DNA and other polydeoxynucleotides to form irreversibly polymer-bound drugs. Consequently, they have been the target of several syntheses as well as screening of natural sources to discover new members. This review provides an update on recent discoveries of PBDs as well as a compilation of spectroscopic data described in the literature.
Keywords: Pyrrolo[1,4]benzodiazepines (PBDs), biological activity, natural products
Mini-Reviews in Organic Chemistry
Title: Naturally Occuring Pyrrolo[1,4]benzodiazepines in Bacteria
Volume: 7 Issue: 1
Author(s): Serge Fotso
Affiliation:
Keywords: Pyrrolo[1,4]benzodiazepines (PBDs), biological activity, natural products
Abstract: Pyrrolo[1,4]benzodiazepines (PBDs) are a growing group of microbial secondary metabolites that showed remarkable biological activities particularly against tumor cells. Their antitumor activity is mainly due to their specifically binding to DNA and other polydeoxynucleotides to form irreversibly polymer-bound drugs. Consequently, they have been the target of several syntheses as well as screening of natural sources to discover new members. This review provides an update on recent discoveries of PBDs as well as a compilation of spectroscopic data described in the literature.
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Fotso Serge, Naturally Occuring Pyrrolo[1,4]benzodiazepines in Bacteria, Mini-Reviews in Organic Chemistry 2010; 7 (1) . https://dx.doi.org/10.2174/1570193X11007010068
DOI https://dx.doi.org/10.2174/1570193X11007010068 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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