Abstract
Cystic Fibrosis (CF) is a chronic, multi-system disorder that primarily affects the lungs, and pancreas, and leads to significant and progressive bronchiectasis, and subsequently end-stage lung disease. Sleep disturbances in cystic fibrosis include nocturnal hypoxemia due to a variety of physiologic changes including ventilation-perfusion mismatch, changes in mechanics of breathing. Derecruitment of ventilatory muscles, particularly during REM sleep and resultant hypoventilation may also be contributory, and may also lead to sleep-disordered breathing in these patients. Other potential causes of sleep disruption in CF patients include nocturnal wheezing and cough, as well as side effects of medications such as β-agonists, as well as chronic pain syndromes. It is likely that sleep fragmentation contributes significantly to impaired quality of life in CF patients. Nocturnal ventilation has been shown to improve symptoms, reverse hypoventilation and increase exercise capacity in CF patients.
Keywords: Sleep, cystic fibrosis, bronchospasm, nocturnal respiratory failure
Current Respiratory Medicine Reviews
Title: Sleep Disturbances in Cystic Fibrosis
Volume: 5 Issue: 4
Author(s): Amarbir S. Mattewal and Shyamsunder Subramanian
Affiliation:
Keywords: Sleep, cystic fibrosis, bronchospasm, nocturnal respiratory failure
Abstract: Cystic Fibrosis (CF) is a chronic, multi-system disorder that primarily affects the lungs, and pancreas, and leads to significant and progressive bronchiectasis, and subsequently end-stage lung disease. Sleep disturbances in cystic fibrosis include nocturnal hypoxemia due to a variety of physiologic changes including ventilation-perfusion mismatch, changes in mechanics of breathing. Derecruitment of ventilatory muscles, particularly during REM sleep and resultant hypoventilation may also be contributory, and may also lead to sleep-disordered breathing in these patients. Other potential causes of sleep disruption in CF patients include nocturnal wheezing and cough, as well as side effects of medications such as β-agonists, as well as chronic pain syndromes. It is likely that sleep fragmentation contributes significantly to impaired quality of life in CF patients. Nocturnal ventilation has been shown to improve symptoms, reverse hypoventilation and increase exercise capacity in CF patients.
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Cite this article as:
Mattewal S. Amarbir and Subramanian Shyamsunder, Sleep Disturbances in Cystic Fibrosis, Current Respiratory Medicine Reviews 2009; 5 (4) . https://dx.doi.org/10.2174/157339809790112401
DOI https://dx.doi.org/10.2174/157339809790112401 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
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