Abstract
A series of chrysin derivatives were prepared from 2-hydroxyacetophenone, 2,4-dihydroxyacetophenone, 2,4,6- trihydroxy- acetophenone, using modified Baker-Venkataraman transformation. Their anticancer activities in vitro were evaluated by the standard MTT method. The results of biological test showed that some of chrysin derivatives showed stronger anticancer activity than 5-fluorouracil.
Medicinal Chemistry
Title: Synthesis and Preliminary Biological Evaluation of Chrysin Derivatives as Potential Anticancer Drugs
Volume: 6 Issue: 1
Author(s): Xing Zheng, Fei Fei Zhao, Yun Mei Liu, Xu Yao, Zi Tong Zheng, Xing Luo and Duan Fang Liao
Affiliation:
Abstract: A series of chrysin derivatives were prepared from 2-hydroxyacetophenone, 2,4-dihydroxyacetophenone, 2,4,6- trihydroxy- acetophenone, using modified Baker-Venkataraman transformation. Their anticancer activities in vitro were evaluated by the standard MTT method. The results of biological test showed that some of chrysin derivatives showed stronger anticancer activity than 5-fluorouracil.
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Cite this article as:
Zheng Xing, Zhao Fei Fei, Mei Liu Yun, Yao Xu, Zheng Zi Tong, Luo Xing and Liao Duan Fang, Synthesis and Preliminary Biological Evaluation of Chrysin Derivatives as Potential Anticancer Drugs, Medicinal Chemistry 2010; 6 (1) . https://dx.doi.org/10.2174/157340610791208763
DOI https://dx.doi.org/10.2174/157340610791208763 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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Carbohydrates are the most essential organic molecules and are involved in the maintenance of various physiological and metabolic processes in living organisms. Carbohydrate-based compounds have come to the attention of researchers because of their significant contributions to biological functions, such as cell development and cell proliferation, connections between several cells, ...read more
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Scope of the Thematic Issue: Correlation between structure and function is one of the important aspects of the success of anti-cancer compounds associated with their structure-activity interactions, physiology, biochemical, molecular, and genetic processes. Overcoming these obstacles is key to obtaining further insights into developments in rational drug design, bioorganic chemistry, ...read more
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