Abstract
Human E1 is a key player in protein ubiquitination, however the E1 structure is not available. In this paper, we describe the derivation of a human E1 structure using molecular modelling based on the crystal structure of S. cerevisiae E1 and M. Musculus E1. Key interactions between our E1 model and ubiquitin are also discussed.
Keywords: Ubiquitination, Human E1, Ubiquitin activating enzyme, Homology modelling
Letters in Drug Design & Discovery
Title: Homology Modelling of Human E1 Ubiquitin Activating Enzyme
Volume: 7 Issue: 1
Author(s): Ghali Brahemi, Angelika M. Burger, Andrew D. Westwell and Andrea Brancale
Affiliation:
Keywords: Ubiquitination, Human E1, Ubiquitin activating enzyme, Homology modelling
Abstract: Human E1 is a key player in protein ubiquitination, however the E1 structure is not available. In this paper, we describe the derivation of a human E1 structure using molecular modelling based on the crystal structure of S. cerevisiae E1 and M. Musculus E1. Key interactions between our E1 model and ubiquitin are also discussed.
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Cite this article as:
Brahemi Ghali, Burger M. Angelika, Westwell D. Andrew and Brancale Andrea, Homology Modelling of Human E1 Ubiquitin Activating Enzyme, Letters in Drug Design & Discovery 2010; 7 (1) . https://dx.doi.org/10.2174/157018010789869316
DOI https://dx.doi.org/10.2174/157018010789869316 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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