Abstract
In this paper, we reported the design, and synthesis of a series of novel pterin derivates i.e. 8a∼f, 9a∼f and 10a∼d. Their inhibitory activity against inducible nitric oxide synthase (iNOS) was evaluated in vitro. It was demonstrated that 4-alkoxypterin derivatives with acylation of 2-amino group showed potent inhibitory activity against iNOS, especially 8c, 8f and 10c.
Keywords: Pterin, Tetrahydrobiopterin, Synthesis, Nitric oxide synthase, Inhibitive activity, In vitro
Letters in Drug Design & Discovery
Title: Design and Synthesis of Pterin Derivares as Nitric Oxide Synthase Inhibitors
Volume: 6 Issue: 8
Author(s): Fei Ma, Ping Guo, Lixun Jiang, Mingsheng Feng, Jingbo Shi and Qizheng Yao
Affiliation:
Keywords: Pterin, Tetrahydrobiopterin, Synthesis, Nitric oxide synthase, Inhibitive activity, In vitro
Abstract: In this paper, we reported the design, and synthesis of a series of novel pterin derivates i.e. 8a∼f, 9a∼f and 10a∼d. Their inhibitory activity against inducible nitric oxide synthase (iNOS) was evaluated in vitro. It was demonstrated that 4-alkoxypterin derivatives with acylation of 2-amino group showed potent inhibitory activity against iNOS, especially 8c, 8f and 10c.
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Cite this article as:
Ma Fei, Guo Ping, Jiang Lixun, Feng Mingsheng, Shi Jingbo and Yao Qizheng, Design and Synthesis of Pterin Derivares as Nitric Oxide Synthase Inhibitors, Letters in Drug Design & Discovery 2009; 6 (8) . https://dx.doi.org/10.2174/157018009789353482
DOI https://dx.doi.org/10.2174/157018009789353482 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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