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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Design and Synthesis of Pterin Derivares as Nitric Oxide Synthase Inhibitors

Author(s): Fei Ma, Ping Guo, Lixun Jiang, Mingsheng Feng, Jingbo Shi and Qizheng Yao

Volume 6, Issue 8, 2009

Page: [575 - 578] Pages: 4

DOI: 10.2174/157018009789353482

Price: $65

Abstract

In this paper, we reported the design, and synthesis of a series of novel pterin derivates i.e. 8a∼f, 9a∼f and 10a∼d. Their inhibitory activity against inducible nitric oxide synthase (iNOS) was evaluated in vitro. It was demonstrated that 4-alkoxypterin derivatives with acylation of 2-amino group showed potent inhibitory activity against iNOS, especially 8c, 8f and 10c.

Keywords: Pterin, Tetrahydrobiopterin, Synthesis, Nitric oxide synthase, Inhibitive activity, In vitro


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