Abstract
Leptin is an adipokine that modulates multiple functions including energy homeostasis, thermoregulation, bone metabolism, endocrine and pro-inflammatory immune responses. Several studies have implicated leptin in the pathogenesis of chronic autoimmune inflammatory conditions such as autoimmune encephalomyelitis, intestinal bowel inflammation and type-1 diabetes. This review focuses on the role of leptin in non-autoimmune inflammatory diseases that include renal, liver and lung inflammation, atherosclerosis and metabolic syndrome, Behcets disease and endometriosis.
Keywords: Leptin, inflammation, metabolism
Inflammation & Allergy - Drug Targets (Discontinued)
Title: Leptin in Non-Autoimmune Inflammation
Volume: 8 Issue: 4
Author(s): Chunlin Cai, Bevra H. Hahn, Giuseppe Matarese and Antonio La Cava
Affiliation:
Keywords: Leptin, inflammation, metabolism
Abstract: Leptin is an adipokine that modulates multiple functions including energy homeostasis, thermoregulation, bone metabolism, endocrine and pro-inflammatory immune responses. Several studies have implicated leptin in the pathogenesis of chronic autoimmune inflammatory conditions such as autoimmune encephalomyelitis, intestinal bowel inflammation and type-1 diabetes. This review focuses on the role of leptin in non-autoimmune inflammatory diseases that include renal, liver and lung inflammation, atherosclerosis and metabolic syndrome, Behcets disease and endometriosis.
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Cite this article as:
Cai Chunlin, Hahn H. Bevra, Matarese Giuseppe and La Cava Antonio, Leptin in Non-Autoimmune Inflammation, Inflammation & Allergy - Drug Targets (Discontinued) 2009; 8 (4) . https://dx.doi.org/10.2174/187152809789352168
DOI https://dx.doi.org/10.2174/187152809789352168 |
Print ISSN 1871-5281 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4055 |
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