Enhanced Brain Targeting of Tegafur Using Novel Lactyl Cholesterol Liposome as a Carrier

Title: Enhanced Brain Targeting of Tegafur Using Novel Lactyl Cholesterol Liposome as a Carrier

Volume: 6 Issue: 7

Author(s): Wei Fan, Xiankun Li, Shan Qian, Shan Wang and Yong Wu

Affiliation:

Keywords: Liposome, Liposome ligands, Monocarboxylic acid transport, Tegafur, Blood-brain barrier, Brain targeting

Abstract: A series of lactyl cholesterols as targeting liposome ligands for brain-specific delivery were synthesized. The lactic acid protected by benzyl group was coupled with cholesteryl oligoethylene carboxylate derivatives 3, then deprotected in tetrahydrofuran by Pd/C with H2 to obtain the title compounds La-Lf. As a model drug, tegafur was entrapped by liposmes and lipsomes coated with these ligands for in vivo study, which showed that the ligand could enhance the ability of liposome delivering tegafur across the blood-brain barrier.

Cite this article as:

Fan Wei, Li Xiankun, Qian Shan, Wang Shan and Wu Yong, Enhanced Brain Targeting of Tegafur Using Novel Lactyl Cholesterol Liposome as a Carrier, Letters in Drug Design & Discovery 2009; 6 (7) . https://dx.doi.org/10.2174/157018009789108303