Abstract
A new ethyl 3-(quinazolin-4-ylamino)-1H-pyrrole-2-carboxylate derivative has been designed and synthesized as antitumor agent, which was identified by 1HNMR, 13CNMR, IR, MS and EA. The antitumor activity of the new compound was tested against human pancreatic cancer Miacapa2, pancreatic cancer Panc1, prostate cancer DU145 and prostate cancer PC3 cells in vitro, and the target compound crystal structure has been characterized by x-ray crystal analysis.
Keywords: Derivative, Antitumor, Agent, In vitro, Crystal structure, X-ray crystal analysis
Letters in Drug Design & Discovery
Title: Design, Synthesis, Crystal Structure and Antitumor Activity of A New Ethyl 3-(quinazolin-4-ylamino)-1H-pyrrole-2-carboxylate Derivative
Volume: 6 Issue: 7
Author(s): Youguang Zheng, Xiaoqing Wu, Min Sun, Liuhai Feng, Mingdong Li and Min Ji
Affiliation:
Keywords: Derivative, Antitumor, Agent, In vitro, Crystal structure, X-ray crystal analysis
Abstract: A new ethyl 3-(quinazolin-4-ylamino)-1H-pyrrole-2-carboxylate derivative has been designed and synthesized as antitumor agent, which was identified by 1HNMR, 13CNMR, IR, MS and EA. The antitumor activity of the new compound was tested against human pancreatic cancer Miacapa2, pancreatic cancer Panc1, prostate cancer DU145 and prostate cancer PC3 cells in vitro, and the target compound crystal structure has been characterized by x-ray crystal analysis.
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Cite this article as:
Zheng Youguang, Wu Xiaoqing, Sun Min, Feng Liuhai, Li Mingdong and Ji Min, Design, Synthesis, Crystal Structure and Antitumor Activity of A New Ethyl 3-(quinazolin-4-ylamino)-1H-pyrrole-2-carboxylate Derivative, Letters in Drug Design & Discovery 2009; 6 (7) . https://dx.doi.org/10.2174/157018009789108240
DOI https://dx.doi.org/10.2174/157018009789108240 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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