New Pyrrole Hydrazones Synthesized and Evaluated In Vitro as Potential Tuberculostatics

Title: New Pyrrole Hydrazones Synthesized and Evaluated In Vitro as Potential Tuberculostatics

Volume: 6 Issue: 7

Author(s): A. Bijev, S. Vladimirova and P. Prodanova

Affiliation:

Keywords: Carbohydrazides, Hydrazones, Pyrrole, Synthesis, Tuberculostatics

Abstract: Sixteen hydrazones were synthesized as derivatives of 1H-1-pyrrolylcarbohydrazides. Five products exhibited 68-97% inhibition against Mycobacterium tuberculosis H37Rv at 6.25 μg/mL using MABA, the most active displaying IC50=7.979 μg/mL and IC90 > 100 μg/mL. Activities correlated with the hydrophobic parameters according to second order QSAR model favoring 4.4 LogP 5.2.

Cite this article as:

Bijev A., Vladimirova S. and Prodanova P., New Pyrrole Hydrazones Synthesized and Evaluated In Vitro as Potential Tuberculostatics, Letters in Drug Design & Discovery 2009; 6 (7) . https://dx.doi.org/10.2174/157018009789108268