Abstract
Carbohydrate-protein interactions play a major-role in recognition of cells by external macromolecules. Single saccharide ligands, however, bind only weakly to their protein receptors. Sufficient affinity is achieved by appropriate mutual orientation of the saccharide epitopes and their protein receptors, which allows multiple simultaneous interactions. Solid-supported methods allowing synthesis of multiantennary glycoconjugates have, hence, been under active development. The present paper is a review of the solid-phase protocols useful for preparation of glycoconjugates.
Current Organic Synthesis
Title: Solid-Supported Synthesis of Glycoconjugates
Volume: 6 Issue: 4
Author(s): Harri Lonnberg
Affiliation:
Abstract: Carbohydrate-protein interactions play a major-role in recognition of cells by external macromolecules. Single saccharide ligands, however, bind only weakly to their protein receptors. Sufficient affinity is achieved by appropriate mutual orientation of the saccharide epitopes and their protein receptors, which allows multiple simultaneous interactions. Solid-supported methods allowing synthesis of multiantennary glycoconjugates have, hence, been under active development. The present paper is a review of the solid-phase protocols useful for preparation of glycoconjugates.
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Cite this article as:
Lonnberg Harri, Solid-Supported Synthesis of Glycoconjugates, Current Organic Synthesis 2009; 6 (4) . https://dx.doi.org/10.2174/157017909789108729
DOI https://dx.doi.org/10.2174/157017909789108729 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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