Abstract
Network biology is conceptualized as an interdisciplinary field, lying at the intersection among graph theory, statistical mechanics and biology. Great efforts have been made to promote the concept of network biology and its various applications in life science. In this review, we focus on the modules that are functional entities and building blocks of a complex network. We first introduce the basic concepts and hot spots of network biology, including several network models, general design principles of complex networks in the module point of view, module discovery approaches and the conservation and evolvability of modules. We then present several cases in which the important mechanisms underlying the cellular behavior are revealed in the framework of network, especially, in the concept of module.
Keywords: Network biology, module, network model, module discovery, evolvability
Current Bioinformatics
Title: Modular Organization in a Cell: Concepts and Applications
Volume: 4 Issue: 3
Author(s): Ruolin Yang and Bing Su
Affiliation:
Keywords: Network biology, module, network model, module discovery, evolvability
Abstract: Network biology is conceptualized as an interdisciplinary field, lying at the intersection among graph theory, statistical mechanics and biology. Great efforts have been made to promote the concept of network biology and its various applications in life science. In this review, we focus on the modules that are functional entities and building blocks of a complex network. We first introduce the basic concepts and hot spots of network biology, including several network models, general design principles of complex networks in the module point of view, module discovery approaches and the conservation and evolvability of modules. We then present several cases in which the important mechanisms underlying the cellular behavior are revealed in the framework of network, especially, in the concept of module.
Export Options
About this article
Cite this article as:
Yang Ruolin and Su Bing, Modular Organization in a Cell: Concepts and Applications, Current Bioinformatics 2009; 4 (3) . https://dx.doi.org/10.2174/157489309789071075
DOI https://dx.doi.org/10.2174/157489309789071075 |
Print ISSN 1574-8936 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-392X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Localisation of Endothelin-1 and its Receptors in Vascular Tissue as Seen at the Electron Microscopic Level
Current Vascular Pharmacology Structure and Design of Polycationic Carriers For Gene Delivery
Mini-Reviews in Medicinal Chemistry Type I Interferons: Ancient Peptides with Still Under-Discovered Anti-Cancer Properties
Protein & Peptide Letters Notch-Associated MicroRNAs in Cancer
Current Drug Targets Moving Beyond VEGF for Anti-angiogenesis Strategies in Gynecologic Cancer
Current Pharmaceutical Design Anticancer Activity of the Ascidian Polyclinum Indicum against Cervical Cancer Cells (HeLa) Mediated through Apoptosis Induction
Medicinal Chemistry The Use of Anthracyclines for Therapy of CNS Tumors
Anti-Cancer Agents in Medicinal Chemistry Lectin-Carbohydrate Interactions: Implications for the Development of New Anticancer Agents
Current Medicinal Chemistry Identification of Tyrosine Kinase Src Responsible for Antimicrobial Peptides Production in Bombyx mori
Protein & Peptide Letters AIDS Related Viruses, their Association with Leukemia, and Raf Signaling
Current HIV Research Review of Clinic Trials: Agents Targeting c-Met
Reviews on Recent Clinical Trials Recent Progress in Discovery and Development of Antimitotic Agents
Anti-Cancer Agents in Medicinal Chemistry Synthesis of Substituted Cinnamido Linked Quinazolinone Congeners as Potential Anticancer Agents via Mitochondrial Dependent Intrinsic Apoptotic Pathway
Anti-Cancer Agents in Medicinal Chemistry Apoptosis-Inducing Effects of Amaryllidaceae Alkaloids
Current Medicinal Chemistry Receptor Tyrosine Kinases as Therapeutic Targets in Malignant Glioma
Reviews on Recent Clinical Trials A Review of Pediatric Mediastinal Masses and Castlemans Disease
Current Pediatric Reviews Targeted Therapy for Brain Tumours: Role of PARP Inhibitors
Current Cancer Drug Targets Neurodegeneration in the Brain Tumor Microenvironment: Glutamate in the Limelight
Current Neuropharmacology Iron Chelators in Cancer Chemotherapy
Current Topics in Medicinal Chemistry Peptides for In Vivo Target-Specific Cancer Imaging
Mini-Reviews in Medicinal Chemistry