Abstract
The neutralization of VEGF is the current treatment of choice for age-related macular degeneration. Current approaches include anti-VEGF-antibodies and – Fab Fragments, aptamers, soluble receptors (Traps) and siRNA. The molecular properties of VEGF and its antagonists are reviewed and the pathways of action of these substances are discussed.
Keywords: VEGF, ranibizumab, lucentis, AMD, pegaptanib, VEGF-trap
Mini-Reviews in Medicinal Chemistry
Title: Treating Age-Related Macular Degeneration – Interaction of VEGF-Antagonists with their Target
Volume: 9 Issue: 9
Author(s): A. Klettner and J. Roider
Affiliation:
Keywords: VEGF, ranibizumab, lucentis, AMD, pegaptanib, VEGF-trap
Abstract: The neutralization of VEGF is the current treatment of choice for age-related macular degeneration. Current approaches include anti-VEGF-antibodies and – Fab Fragments, aptamers, soluble receptors (Traps) and siRNA. The molecular properties of VEGF and its antagonists are reviewed and the pathways of action of these substances are discussed.
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Cite this article as:
Klettner A. and Roider J., Treating Age-Related Macular Degeneration – Interaction of VEGF-Antagonists with their Target, Mini-Reviews in Medicinal Chemistry 2009; 9 (9) . https://dx.doi.org/10.2174/138955709788922665
DOI https://dx.doi.org/10.2174/138955709788922665 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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