Abstract
The present review after providing a short overview on PPARs and their pleiotropic action focuses on the QSAR studies reported mainly for PPAR-γ agonists. The different 3D and 2D QSAR models are discussed, their impact in better understanding of the mechanism of action is analyzed and their contribution in the design of new molecules is outlined.
Keywords: PPAR-γ, type II Diabetes, mechanism of action, 3D-QSAR, 2D-QSAR, drug design
Mini-Reviews in Medicinal Chemistry
Title: Structural Basis for the Design of PPAR-γ Ligands: A Survey on Quantitative Structure- Activity Relationships
Volume: 9 Issue: 9
Author(s): Costas Giaginis, Stamatios Theocharis and Anna Tsantili-Kakoulidou
Affiliation:
Keywords: PPAR-γ, type II Diabetes, mechanism of action, 3D-QSAR, 2D-QSAR, drug design
Abstract: The present review after providing a short overview on PPARs and their pleiotropic action focuses on the QSAR studies reported mainly for PPAR-γ agonists. The different 3D and 2D QSAR models are discussed, their impact in better understanding of the mechanism of action is analyzed and their contribution in the design of new molecules is outlined.
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Cite this article as:
Giaginis Costas, Theocharis Stamatios and Tsantili-Kakoulidou Anna, Structural Basis for the Design of PPAR-γ Ligands: A Survey on Quantitative Structure- Activity Relationships, Mini-Reviews in Medicinal Chemistry 2009; 9 (9) . https://dx.doi.org/10.2174/138955709788922601
DOI https://dx.doi.org/10.2174/138955709788922601 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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