Abstract
The acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) are part of a devastating syndrome characterized by acute onset, hypoxemia, and bilateral infiltrates on chest X-rays. ALI/ARDS arises from the lungs response to local or systemic aggression in which local inflammation and coagulation disorders lead to increased inflammatory pulmonary edema. ARDS is a major cause of morbidity, death, and cost in intensive care units. ALI and ARDS are associated with increased procoagulant and reduced fibrinolytic activities mainly in alveoli and interstitial spaces. Fibrin deposition, which is the hallmark of early phase ALI, stimulates fibroblast aggregation and collagen secretion, contributing to pulmonary fibrosis. The only clinical intervention that has a significant impact on mortality in ARDS is the use of low tidal volume ventilation. ARDS has many coagulation disorders in common with severe sepsis, where recombinant human activated protein C has reduced mortality, hastened improvement in respiratory dysfunction, and shortened the duration of mechanical ventilation. Future clinical trials in ALI/ARDS should evaluate the potential benefits of anticoagulants administered systemically or locally in the lungs.
Keywords: Acute respiratory distress syndrome, acute lung injury, coagulation disorders, activated protein C
Current Respiratory Medicine Reviews
Title: Coagulation Disorders in Acute Lung Injury
Volume: 5 Issue: 3
Author(s): Melanie Adda, Ricard Ferrer, Ferranda Puig, Javier Crespo and Antoni Artigas
Affiliation:
Keywords: Acute respiratory distress syndrome, acute lung injury, coagulation disorders, activated protein C
Abstract: The acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) are part of a devastating syndrome characterized by acute onset, hypoxemia, and bilateral infiltrates on chest X-rays. ALI/ARDS arises from the lungs response to local or systemic aggression in which local inflammation and coagulation disorders lead to increased inflammatory pulmonary edema. ARDS is a major cause of morbidity, death, and cost in intensive care units. ALI and ARDS are associated with increased procoagulant and reduced fibrinolytic activities mainly in alveoli and interstitial spaces. Fibrin deposition, which is the hallmark of early phase ALI, stimulates fibroblast aggregation and collagen secretion, contributing to pulmonary fibrosis. The only clinical intervention that has a significant impact on mortality in ARDS is the use of low tidal volume ventilation. ARDS has many coagulation disorders in common with severe sepsis, where recombinant human activated protein C has reduced mortality, hastened improvement in respiratory dysfunction, and shortened the duration of mechanical ventilation. Future clinical trials in ALI/ARDS should evaluate the potential benefits of anticoagulants administered systemically or locally in the lungs.
Export Options
About this article
Cite this article as:
Adda Melanie, Ferrer Ricard, Puig Ferranda, Crespo Javier and Artigas Antoni, Coagulation Disorders in Acute Lung Injury, Current Respiratory Medicine Reviews 2009; 5 (3) . https://dx.doi.org/10.2174/157339809788922342
DOI https://dx.doi.org/10.2174/157339809788922342 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
Call for Papers in Thematic Issues
Exposure to PM2.5 components is associated with respiratory diseases
Through continuous research on the relationship between risk factors and health, it has been found that air pollution, especially atmospheric particulate matter pollution, has become one of the main sources of global disease burden. From 1990 to 2022, the concentration of atmospheric particulate matter pollution has increased by more than ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Angiogenic and Anti-Angiogenic Therapy for Gastrointestinal Ulcers: New Challenges for Rational Therapeutic Predictions and Drug Design
Current Pharmaceutical Design Drug-Induced Peripheral Neuropathy: Diagnosis and Management
Current Cancer Drug Targets The Role of T-Helper Cells in Atherosclerosis
Cardiovascular & Hematological Agents in Medicinal Chemistry Mouse Models of Autoimmune Diseases - Autoimmune Myocarditis
Current Pharmaceutical Design Patent Annotations
Recent Patents on Cardiovascular Drug Discovery Impact of COVID-19 on Indian Pharmaceutical Industry and Way Forward
Infectious Disorders - Drug Targets Clinical Applications of Non-Antimicrobial Actions of Tetracyclines in Inflammatory Diseases
Current Drug Therapy Identification of New Pancreatic Beta Cell Targets for In Vivo Imaging by a Systems Biology Approach
Current Pharmaceutical Design Natural COX-2 Inhibitors as Promising Anti-inflammatory Agents: An Update
Current Medicinal Chemistry Treatment for Diabetic Peripheral Neuropathy: What have we Learned from Animal Models?
Current Diabetes Reviews Potential Efficacy of Some African Plants in Benign Prostatic Hyperplasia and Prostate Cancer
Mini-Reviews in Medicinal Chemistry Treating High Density Lipoprotein Cholesterol (HDL-C): Quantity Versus Quality
Current Pharmaceutical Design Proteins of the Esterase Family: Patents for Some Proteins in Search of Metabolic Functions
Recent Patents on Biomarkers Therapeutic Potential of Plant Extracts and Phytochemicals Against Brain Ischemia-Reperfusion Injury: A Review
The Natural Products Journal Genetics and Genomics of Hepatic Acute Phase Reactants: A Mini-Review
Inflammation & Allergy - Drug Targets (Discontinued) Oxidative Stress Biology and Cell Injury During Type 1 and Type 2 Diabetes Mellitus
Current Neurovascular Research Post-Exercise Ketosis, Salivary Uric Acid and Interleukin-6 after a Simulated Wheelchair Basketball Match
Endocrine, Metabolic & Immune Disorders - Drug Targets Antioxidant Therapy for the Treatment of Oxidative Stress Associated to Cancer and Cancer- Related Anorexia/Cachexia
Current Nutrition & Food Science Assessment of Adverse Drug Reaction Due to Cancer Chemotherapy in a Teaching Oncology Hospital in Isfahan, Central of Iran
Reviews on Recent Clinical Trials Current and Future Challenges in Primary Sjogren’s Syndrome
Current Pharmaceutical Biotechnology