Perfluoroalkylsulfonyloxyisoflavones: Synthesis and Anti-Proliferation of HL-60

Title: Perfluoroalkylsulfonyloxyisoflavones: Synthesis and Anti-Proliferation of HL-60

Volume: 6 Issue: 5

Author(s): Hongqi Li and Ye Jin

Affiliation:

Keywords: Isoflavone, perfluoroalkylsulfonate, regioselectivity, HL-60

Abstract: Isoflavonoids containing a perfluoroalkylsulfonyloxy group were synthesized by perfluoroalkylsulfonylation of hydroxyisoflavones. The reaction showed high regioselectivity. Inhibitory effects of the synthesized isoflavones against proliferation of HL-60 and BEL-7402 cells were tested in vitro. Two isoflavones displayed strong inhibitory effect on HL- 60 cells.

Cite this article as:

Li Hongqi and Jin Ye, Perfluoroalkylsulfonyloxyisoflavones: Synthesis and Anti-Proliferation of HL-60, Letters in Organic Chemistry 2009; 6 (5) . https://dx.doi.org/10.2174/157017809788681257