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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Revised Structure of Penicillazine and Preparation, Bioactivities of Penicillazine Derivatives

Author(s): Chang-Lun Shao, Chang-Yun Wang, Yu-Cheng Gu, Ji-Wen Cai, Dong-Sheng Deng, Zhi-Gang She and Yong-Cheng Lin

Volume 6, Issue 5, 2009

Page: [387 - 391] Pages: 5

DOI: 10.2174/157017809788681301

Price: $65

Abstract

The structure of penicillazine has been revised on the basis of hydrolysis reaction. Its absolute stereochemistry has been confirmed by X-ray diffraction using copper radiation. Eight new penicillazine derivatives (1-8) were prepared and some of them showed higher levels of activity than penicillazine against α-glucosidase and Human DNA topoisomerase I.

Keywords: Penicillazine, derivatives, structure revision, biological activities, α-glucosidase, Human DNA topoisomerase I


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