Generic placeholder image

Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Disodium Phosphate of Norcantharidin Analogues: Design, Synthesis and their Anticancer Evaluation

Author(s): Liping Deng, Yongmiao Shen, Wei Wang, Weifeng Tao, Jianguo Lv and Chunlei Wu

Volume 6, Issue 5, 2009

Page: [345 - 352] Pages: 8

DOI: 10.2174/1570180810906050345

Price: $65

Abstract

To design and synthesize disodium phosphate of novel norcanthridin analogues. All analogues have been screened for their antiproliferative activity in vitro against a panel of tumour cell lines: SMMC-7721, SGC7901, ECA109, A549 and MCF-7 producing IC50 values from 0.15 μM to > 50 μM. Compounds 6 and 17 showed potency for the treatment of mammary adenocarcinoma, with IC value to MCF-7 cell line comparable to that of cantharidin, which proves that the phosphorylation of norcantharidin analogues is an effective way to increase the activity and solubility.

Keywords: Norcantharidin analogues, Phosphorylation, Anticancer evaluation, Solubility


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy