Abstract
A concise account of the physicochemical properties of morphine and its derivatives of therapeutic interest is provided. Such properties include macroscopic and microscopic acid/base parameters, lipophilicity, solubility, permeability that all influence the fate of drugs in the body. The dependence of these parameters on pH is discussed and subsequent implications in drug administration and formulation are presented.
Keywords: Morphine, pharmacokinetic properties, physicochemical profiling, acid/base properties, lipophilicity, solubility, permeability, stability
Mini-Reviews in Medicinal Chemistry
Title: Structural and Physicochemical Profiling of Morphine and Related Compounds of Therapeutic Interest
Volume: 9 Issue: 8
Author(s): K. Mazak, S. Hosztafi, A. Racz and B. Noszal
Affiliation:
Keywords: Morphine, pharmacokinetic properties, physicochemical profiling, acid/base properties, lipophilicity, solubility, permeability, stability
Abstract: A concise account of the physicochemical properties of morphine and its derivatives of therapeutic interest is provided. Such properties include macroscopic and microscopic acid/base parameters, lipophilicity, solubility, permeability that all influence the fate of drugs in the body. The dependence of these parameters on pH is discussed and subsequent implications in drug administration and formulation are presented.
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Cite this article as:
Mazak K., Hosztafi S., Racz A. and Noszal B., Structural and Physicochemical Profiling of Morphine and Related Compounds of Therapeutic Interest, Mini-Reviews in Medicinal Chemistry 2009; 9 (8) . https://dx.doi.org/10.2174/138955709788681555
DOI https://dx.doi.org/10.2174/138955709788681555 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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