Abstract
Employing a flexible synthetic strategy towards laurenditerpenol, two analogues featuring the 7- oxabicyclo[2.2.1]heptane ring system present in the natural product have been prepared and their ability to inhibit HIF-1 activation has been evaluated. Their weak activity indicates the importance of the cyclohexenol part of the prototype.
Keywords: Furan, Diels-Alder reaction, Olefin cross-metathesis, Natural products
Letters in Organic Chemistry
Title: Synthesis of Novel Laurenditerpenol Analogues and their Evaluation as HIF-1 Activation Inhibitors
Volume: 6 Issue: 4
Author(s): Nikolaos Athinaios, Athanasios Kazantzis, Kerstin Putzker, Joe Lewis and Emmanuel N. Pitsinos
Affiliation:
Keywords: Furan, Diels-Alder reaction, Olefin cross-metathesis, Natural products
Abstract: Employing a flexible synthetic strategy towards laurenditerpenol, two analogues featuring the 7- oxabicyclo[2.2.1]heptane ring system present in the natural product have been prepared and their ability to inhibit HIF-1 activation has been evaluated. Their weak activity indicates the importance of the cyclohexenol part of the prototype.
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Cite this article as:
Athinaios Nikolaos, Kazantzis Athanasios, Putzker Kerstin, Lewis Joe and Pitsinos N. Emmanuel, Synthesis of Novel Laurenditerpenol Analogues and their Evaluation as HIF-1 Activation Inhibitors, Letters in Organic Chemistry 2009; 6 (4) . https://dx.doi.org/10.2174/157017809788489891
DOI https://dx.doi.org/10.2174/157017809788489891 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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