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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Recent Advances in Synthesis of PAR Ligands as Therapeutic Strategy for Inflammatory Diseases

Author(s): B. Severino, V. Santagada, E. Perissutti, F. Fiorino, F. Frecentese, F. De Angelis, A. Esposito and G. Caliendo

Volume 9, Issue 6, 2009

Page: [653 - 663] Pages: 11

DOI: 10.2174/138955709788452711

Price: $65

Abstract

Several studies have been published on discovering involvement of PARs receptors in a number of disease states, including cancer and inflammation of the cardiovascular, respiratory, musculoskeletal, gastrointestinal and nervous systems. This mini-review will focus on recent advances in the synthesis of PAR ligands highlighting their therapeutic potential in the treatment of various inflammatory diseases.

Keywords: Protease activated receptors, inflammation, agonist, antagonist, peptide-mimetic, small-molecule


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