Triethylamine Promoted Efficient Synthesis of 3,4-Dihydropyrimidin- 2(1H)-ones/thiones Using a Solvent-Free Biginelli Condensation

Title: Triethylamine Promoted Efficient Synthesis of 3,4-Dihydropyrimidin- 2(1H)-ones/thiones Using a Solvent-Free Biginelli Condensation

Volume: 7 Issue: 4

Author(s): Abdelmadjid Debache, Wassima Ghalem, Raouf Boulcina, Ali Belfaitah, Salah Rhouati and Bertrand Carboni

Affiliation:

Keywords: Triethylamine, Bronsted bases, multicomponent reaction, 3,4-dihydropyrimidin-2(1H)-ones/thiones, Biginelli reaction, one-pot condensation

Abstract: An efficient and simple protocol has been developed for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones by a one-pot three-component cyclocondensation reaction of an aromatic aldehyde, β-ketoester, and urea or thiourea under solvent-free conditions using triethylamine (Et3N) as catalyst for the Biginelli reaction.

Cite this article as:

Debache Abdelmadjid, Ghalem Wassima, Boulcina Raouf, Belfaitah Ali, Rhouati Salah and Carboni Bertrand, Triethylamine Promoted Efficient Synthesis of 3,4-Dihydropyrimidin- 2(1H)-ones/thiones Using a Solvent-Free Biginelli Condensation, Letters in Organic Chemistry 2010; 7 (4) . https://dx.doi.org/10.2174/157017810791130595