Abstract
Terpenoids are natural products of great interest due to their broad application scope. They are employed as agrochemicals, drugs, fragrances, flavours and pigments. In the search of new derivatives with improved properties, the use of biocatalysts is being constantly increased, especially in redox processes. They can give rise to stereo- and regioselective products and/or compounds functionalized in remote positions difficult to reach by means of traditional organic chemistry. In this review, the application of whole cell catalyzed biotransformations of terpenoids to obtain new drug targets or to increase the pharmacological activity is presented.
Keywords: Terpenes, terpenoids, biotransformations, enzymes, redox process
Mini-Reviews in Organic Chemistry
Title: Biotransformation of Terpenoids: A Green Alternative for Producing Molecules with Pharmacological Activity
Volume: 6 Issue: 2
Author(s): Y. Simeo and J. V. Sinisterra
Affiliation:
Keywords: Terpenes, terpenoids, biotransformations, enzymes, redox process
Abstract: Terpenoids are natural products of great interest due to their broad application scope. They are employed as agrochemicals, drugs, fragrances, flavours and pigments. In the search of new derivatives with improved properties, the use of biocatalysts is being constantly increased, especially in redox processes. They can give rise to stereo- and regioselective products and/or compounds functionalized in remote positions difficult to reach by means of traditional organic chemistry. In this review, the application of whole cell catalyzed biotransformations of terpenoids to obtain new drug targets or to increase the pharmacological activity is presented.
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Cite this article as:
Simeo Y. and Sinisterra V. J., Biotransformation of Terpenoids: A Green Alternative for Producing Molecules with Pharmacological Activity, Mini-Reviews in Organic Chemistry 2009; 6 (2) . https://dx.doi.org/10.2174/157019309788167710
DOI https://dx.doi.org/10.2174/157019309788167710 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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