Endotoxin-Neutralizing Peptides as Gram-Negative Sepsis Therapeutics

Title: Endotoxin-Neutralizing Peptides as Gram-Negative Sepsis Therapeutics

Volume: 16 Issue: 5

Author(s): Kwong-Fai Wong and John M. Luk

Affiliation:

Keywords: Endotoxin-neutralizing peptide, BPIP, anti-microbial peptide, CD18, gram-negative sepsis

Abstract: Bacterial endotoxin [e.g. lipopolysaccharide (LPS)] can trigger systemic hyper-inflammatory that subsequently leads to multiple organ failure and lethality (gram-negative sepsis). This paper describes the development of endotoxinneutralizing peptides that potentially treat sepsis. These peptides have been derived from bactericidal/permeabilityincreasing protein (BPIP), anti-microbial peptides, and leukocyte CD18 antigen and some of these peptides have been tested in clinical studies.

Cite this article as:

Wong Kwong-Fai and Luk M. John, Endotoxin-Neutralizing Peptides as Gram-Negative Sepsis Therapeutics, Protein & Peptide Letters 2009; 16 (5) . https://dx.doi.org/10.2174/092986609788167761