Abstract
A huge number of organophosphate poisonings occurring in agriculture, and a constant threat of misapplication of organophosphates as warfare agents require antidotes that efficiently improve the health-condition of intoxicated subjects. Pyridinium aldoximes are medically used to reactivate the cholinesterase enzymes inhibited by organophosphates. This paper outlines pharmacokinetics, metabolic disposition and blood-brain-barrier penetration of pyridinium aldoximes into the human and animal body, and the methods of their pharmacological analysis.
Keywords: Pyridinium aldoximes, pralidoxime, K-27, K-48, K-203
Mini-Reviews in Medicinal Chemistry
Title: Monitoring the Pharmacokinetics of Pyridinium Aldoximes in the Body
Volume: 9 Issue: 5
Author(s): H. Kalasz, J. Furesz and K. Tekes
Affiliation:
Keywords: Pyridinium aldoximes, pralidoxime, K-27, K-48, K-203
Abstract: A huge number of organophosphate poisonings occurring in agriculture, and a constant threat of misapplication of organophosphates as warfare agents require antidotes that efficiently improve the health-condition of intoxicated subjects. Pyridinium aldoximes are medically used to reactivate the cholinesterase enzymes inhibited by organophosphates. This paper outlines pharmacokinetics, metabolic disposition and blood-brain-barrier penetration of pyridinium aldoximes into the human and animal body, and the methods of their pharmacological analysis.
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Cite this article as:
Kalasz H., Furesz J. and Tekes K., Monitoring the Pharmacokinetics of Pyridinium Aldoximes in the Body, Mini-Reviews in Medicinal Chemistry 2009; 9 (5) . https://dx.doi.org/10.2174/138955709788167565
DOI https://dx.doi.org/10.2174/138955709788167565 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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