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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Monitoring the Pharmacokinetics of Pyridinium Aldoximes in the Body

Author(s): H. Kalasz, J. Furesz and K. Tekes

Volume 9, Issue 5, 2009

Page: [596 - 610] Pages: 15

DOI: 10.2174/138955709788167565

Price: $65

Abstract

A huge number of organophosphate poisonings occurring in agriculture, and a constant threat of misapplication of organophosphates as warfare agents require antidotes that efficiently improve the health-condition of intoxicated subjects. Pyridinium aldoximes are medically used to reactivate the cholinesterase enzymes inhibited by organophosphates. This paper outlines pharmacokinetics, metabolic disposition and blood-brain-barrier penetration of pyridinium aldoximes into the human and animal body, and the methods of their pharmacological analysis.

Keywords: Pyridinium aldoximes, pralidoxime, K-27, K-48, K-203


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