Abstract
We report a case with severe persistent pulmonary hypertension (PPHN) associated with congenital cystic adenomatoid malformation of the lung (CCAM) treated with sildenafil PO. The case was unresponsive to the High-Frequency Oscillatory Ventilation (HFOV), with a oxygenation index (OI) of 50 before sildenafil. Substantial improvement in OI was followed by extubation and survival. No side-effects were noted.
Keywords: PPHN, CCAM, sildenafil, HFOV, oxygenation index
Current Pediatric Reviews
Title: Neonatal Persistent Pulmonary Hypertension Associated with Congenital Cystic Adenomatoid Malformation Treated with Sildenafil: Case Report
Volume: 5 Issue: 2
Author(s): Gianfranco Maffei, Vincenzo Manuppelli and Rosario Magaldi
Affiliation:
Keywords: PPHN, CCAM, sildenafil, HFOV, oxygenation index
Abstract: We report a case with severe persistent pulmonary hypertension (PPHN) associated with congenital cystic adenomatoid malformation of the lung (CCAM) treated with sildenafil PO. The case was unresponsive to the High-Frequency Oscillatory Ventilation (HFOV), with a oxygenation index (OI) of 50 before sildenafil. Substantial improvement in OI was followed by extubation and survival. No side-effects were noted.
Export Options
About this article
Cite this article as:
Maffei Gianfranco, Manuppelli Vincenzo and Magaldi Rosario, Neonatal Persistent Pulmonary Hypertension Associated with Congenital Cystic Adenomatoid Malformation Treated with Sildenafil: Case Report, Current Pediatric Reviews 2009; 5 (2) . https://dx.doi.org/10.2174/157339609788185767
DOI https://dx.doi.org/10.2174/157339609788185767 |
Print ISSN 1573-3963 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6336 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Editorial [Hot Topic: Latest Developments in Pharmaceutical Design of Arachidonic Acid Metabolites: Prostaglandins, Thromboxanes, Hepoxilins and Isoprostanes (Executive Editors: J.-M. Dogne and K.-H. Ruan )]
Current Pharmaceutical Design Dissolution Enhancement of Eplerenone using Solvent Melt Method
Drug Delivery Letters Towards Standardized Stem Cell Therapy in Type 2 Diabetes Mellitus: A Systematic Review
Current Stem Cell Research & Therapy Abnormal Peri-Organ or Intra-organ Fat (APIFat) Deposition: An Underestimated Predictor of Vascular Risk?
Current Vascular Pharmacology Protective Role of Melatonin in Liver Damage
Current Pharmaceutical Design Donepezil Improves Gait Performance in Patients with an Acute Cerebral Infarction: A Prospective Observational Cohort Study
Current Neurovascular Research Marine Food Protection in Testicular Damages Caused by Diabetes Mellitus
Current Diabetes Reviews Obstructive Sleep Apnea and Stroke
Current Respiratory Medicine Reviews Angiogenesis as Risk Factor for Plaque Vulnerability
Current Pharmaceutical Design The Role of Cannabinoid Receptors in Renal Diseases
Current Medicinal Chemistry Rimonabant for the Treatment of Obesity
Recent Patents on Cardiovascular Drug Discovery HELLP Syndrome: Pathophysiology and Current Therapies
Current Pharmaceutical Biotechnology Impact of Pre-Diabetes and Diabetes on Cardiovascular Outcomes
Current Vascular Pharmacology TiO2-Nanowired Delivery of Mesenchymal Stem Cells Thwarts Diabetes- Induced Exacerbation of Brain Pathology in Heat Stroke: An Experimental Study in the Rat Using Morphological and Biochemical Approaches
CNS & Neurological Disorders - Drug Targets Emerging Therapies for Diabetic Neuropathy: A Clinical Overview
Current Diabetes Reviews High Throughput Metabolomics in Clinical Studies: Review and New Applications to Remote Ischemic Preconditioning
Current Topics in Medicinal Chemistry Crosstalk between Oxidative and Nitrosative Stress and Arterial Stiffness
Current Vascular Pharmacology Effect of Colestimide on Reduction of Body Weight and Waist Circumference in Metabolic Syndrome Patients with Cardiovascular Risk Factors
Vascular Disease Prevention (Discontinued) Helicobacter pylori Eradication Improves the Malnutrition, Inflammation and Atherosclerosis Syndrome in Peritoneal Dialysis Patients
Vascular Disease Prevention (Discontinued) Safety and Efficacy of Novel Oral Anticoagulants: A Comparison to Vitamin K Antagonists
Cardiovascular & Hematological Agents in Medicinal Chemistry