Abstract
The concentration of airborne particulate matters (PM) is related to daily hospital admissions for several pulmonary disorders such as bronchial asthma, acute and chronic bronchiolitis, and pneumonia. Especially, PM with a mass median aerodynamic diameter < or 2.5 μm (PM2.5) is recognized to be more closely associated with respiratory effects and subsequent mortality than that of mass median aerodynamic diameter < or 10 μm (PM10). However, there has been insufficient experimental evidence and their underlying mechanisms to support these epidemiological investigations. In this review, we introduce the adverse effects of PM, particularly, diesel exhaust particles, the main constituents of PM, on several pulmonary diseases, showing our in vivo evidence. Further, we also focus on the effects of nanoparticles, particles less than 100 nm in mass median aerodynamic diameter, on respiratory tract and disorders.
Keywords: Particulate matters, diesel exhaust particles, nanoparticles, acute lung inflammation, allergic asthma
Current Respiratory Medicine Reviews
Title: Airborne Particles in Pulmonary Diseases
Volume: 5 Issue: 2
Author(s): Ken-ichiro Inoue, Hirohisa Takano, Rie Yanagisawa and Toshikazu Yoshikawa
Affiliation:
Keywords: Particulate matters, diesel exhaust particles, nanoparticles, acute lung inflammation, allergic asthma
Abstract: The concentration of airborne particulate matters (PM) is related to daily hospital admissions for several pulmonary disorders such as bronchial asthma, acute and chronic bronchiolitis, and pneumonia. Especially, PM with a mass median aerodynamic diameter < or 2.5 μm (PM2.5) is recognized to be more closely associated with respiratory effects and subsequent mortality than that of mass median aerodynamic diameter < or 10 μm (PM10). However, there has been insufficient experimental evidence and their underlying mechanisms to support these epidemiological investigations. In this review, we introduce the adverse effects of PM, particularly, diesel exhaust particles, the main constituents of PM, on several pulmonary diseases, showing our in vivo evidence. Further, we also focus on the effects of nanoparticles, particles less than 100 nm in mass median aerodynamic diameter, on respiratory tract and disorders.
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Cite this article as:
Inoue Ken-ichiro, Takano Hirohisa, Yanagisawa Rie and Yoshikawa Toshikazu, Airborne Particles in Pulmonary Diseases, Current Respiratory Medicine Reviews 2009; 5 (2) . https://dx.doi.org/10.2174/157339809788189941
DOI https://dx.doi.org/10.2174/157339809788189941 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
Call for Papers in Thematic Issues
Exposure to PM2.5 components is associated with respiratory diseases
Through continuous research on the relationship between risk factors and health, it has been found that air pollution, especially atmospheric particulate matter pollution, has become one of the main sources of global disease burden. From 1990 to 2022, the concentration of atmospheric particulate matter pollution has increased by more than ...read more
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