Abstract
N-substituted 1,4-dihydropyridines bearing a carboxyl group at the 4-position were synthesized in solvent-free conditions with Cu2+ as the catalyst, imine and β-ketoester as starting materials. The possible mechanism which consists of addition-rearrangement process was proposed and examined by the reaction of isolated product of first addition to β- ketoester.
Keywords: Dihydropyridines, addition-rearrangement, Cu2+-catalyzed, imines, β-ketoester, solvent-free
Letters in Organic Chemistry
Title: Synthesis of New 1, 4-Dihydropyridines by Addition-Rearrangement Process with Imine Derivatives and β-Ketoester as Starting Materials in Solvent-Free Conditions (SUPPORTING INFORMATION)
Volume: 6 Issue: 3
Author(s): Xueming Chen, Xiaoguang Huang, Yunyun Chen, Feng He and Xingshu Li
Affiliation:
Keywords: Dihydropyridines, addition-rearrangement, Cu2+-catalyzed, imines, β-ketoester, solvent-free
Abstract: N-substituted 1,4-dihydropyridines bearing a carboxyl group at the 4-position were synthesized in solvent-free conditions with Cu2+ as the catalyst, imine and β-ketoester as starting materials. The possible mechanism which consists of addition-rearrangement process was proposed and examined by the reaction of isolated product of first addition to β- ketoester.
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Cite this article as:
Chen Xueming, Huang Xiaoguang, Chen Yunyun, He Feng and Li Xingshu, Synthesis of New 1, 4-Dihydropyridines by Addition-Rearrangement Process with Imine Derivatives and β-Ketoester as Starting Materials in Solvent-Free Conditions (SUPPORTING INFORMATION), Letters in Organic Chemistry 2009; 6 (3) . https://dx.doi.org/10.2174/157017809787893082
DOI https://dx.doi.org/10.2174/157017809787893082 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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