Hydroxamic Acids Designed as Inhibitors of Urease

Title: Hydroxamic Acids Designed as Inhibitors of Urease

Volume: 6 Issue: 3

Author(s): Thalita G. Barros, John S. Williamson, O. A.C. Antunes and Estela M.F. Muri

Affiliation:

Keywords: Hydroxamic acids, Urease, Gastritis, Inhibitors

Abstract: Urease is an enzyme responsible for the hydrolysis of urea into ammonia and carbamate. Humans infected by urease are exposed to a risk of chronic gastritis or cancer. Urease inhibitors have attracted a great deal of attention for their potential as new anti-ulcer drugs. Here, we describe the synthesis of series of hydroxamic acid compounds designed as inhibitors of urease.

Cite this article as:

Barros G. Thalita, Williamson S. John, Antunes A.C. O. and Muri M.F. Estela, Hydroxamic Acids Designed as Inhibitors of Urease, Letters in Drug Design & Discovery 2009; 6 (3) . https://dx.doi.org/10.2174/157018009787847783