Abstract
Some novel benzoquinones and their dimethoxy chemical precursors were synthesized based on shikonin structural features. The quinone functionality showed strong .OH radical scavenging, whereas benzoquinones with an α- hydroxy-containing saturated side chain exhibited increased soybean lipoxygenase inhibition. Compounds 5, 5b and 7 were superior to indomethacin in vivo in the carrageenin-induced rat paw edema inhibition.
Keywords: Shikonin, Inflammation, Psoriasis, LOX, Radical scavengers, Benzoquinones
Letters in Drug Design & Discovery
Title: Synthesis of Novel Benzoquinones with Anti-Inflammatory Activity
Volume: 6 Issue: 3
Author(s): Marina Sagnou, Alexandros Strongilos, Dimitra Hadjipavlou-Litina and Elias A. Couladouros
Affiliation:
Keywords: Shikonin, Inflammation, Psoriasis, LOX, Radical scavengers, Benzoquinones
Abstract: Some novel benzoquinones and their dimethoxy chemical precursors were synthesized based on shikonin structural features. The quinone functionality showed strong .OH radical scavenging, whereas benzoquinones with an α- hydroxy-containing saturated side chain exhibited increased soybean lipoxygenase inhibition. Compounds 5, 5b and 7 were superior to indomethacin in vivo in the carrageenin-induced rat paw edema inhibition.
Export Options
About this article
Cite this article as:
Sagnou Marina, Strongilos Alexandros, Hadjipavlou-Litina Dimitra and Couladouros A. Elias, Synthesis of Novel Benzoquinones with Anti-Inflammatory Activity, Letters in Drug Design & Discovery 2009; 6 (3) . https://dx.doi.org/10.2174/157018009787847792
DOI https://dx.doi.org/10.2174/157018009787847792 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Role of Renin-Angiotensin System in Vascular Endothelial Dysfunction of Pregnancy-Induced Hypertension
Current Hypertension Reviews Lipid Profile of Pig Tissues Contrasting in Meat Production
The Natural Products Journal Potential Roles of HDAC Inhibitors in Mitigating Ischemia-induced Brain Damage and Facilitating Endogenous Regeneration and Recovery
Current Pharmaceutical Design Why is the Inhibition of the Renin-Angiotensin System Effective for Preventing Cardiac Events in Patients with Coronary Risk Factors or Coronary Artery Disease?
Current Cardiology Reviews Coronary Intravascular Ultrasound (IVUS): Contemporary Applications and Bases for the Future
Recent Patents on Medical Imaging Regression of Oxidative Stress by Targeting eNOS and Nrf2/ARE Signaling: A Guided Drug Target for Cardiovascular Diseases
Current Topics in Medicinal Chemistry Ecto-Nucleotidase Inhibitors: Recent Developments in Drug Discovery
Mini-Reviews in Medicinal Chemistry Beta-adrenergic Signaling: Complexities and Therapeutic Relevance to Heart Failure
Current Signal Transduction Therapy Endothelial Expression of MHC Class II Molecules in Autoimmune Disease
Current Pharmaceutical Design Transport of Nucleoside Analogs Across the Plasma Membrane: A Clue to Understanding Drug-Induced Cytotoxicity
Current Drug Metabolism Design of Multifunctional Compounds for Cardiovascular Disease: From Natural Scaffolds to “Classical” Multitarget Approach
Current Medicinal Chemistry The Role of Renin Angiotensin System Blockade in the Treatment of Atrial Fibrillation
Current Drug Targets - Cardiovascular & Hematological Disorders The Synthetic Cannabinoids Phenomenon
Current Pharmaceutical Design Functional and Molecular Ultrasound Imaging: Concepts and Contrast Agents
Current Medicinal Chemistry Peptide5 Attenuates rtPA Related Brain Microvascular Endothelial Cells Reperfusion Injury via the Wnt/β-Catenin Signalling Pathway
Current Neurovascular Research The Pathogenic Subpopulation of Th17 Cells in Obesity
Current Pharmaceutical Design Adenosine in the Inflamed Gut: A Janus Faced Compound
Current Medicinal Chemistry Targeting Apelinergic System in Cardiometabolic Disease
Current Drug Targets Subject Index to Volume 1
Current Vascular Pharmacology Inhibition of sPLA2-IIA, C-reactive Protein or Complement: New Therapy for Patients with Acute Myocardial Infarction?
Cardiovascular & Hematological Disorders-Drug Targets