Total Synthesis of Cyclosporin O: Exploring the Utility of Bsmoc-NMe- Amino Acid Fluorides and KOAt

Title: Total Synthesis of Cyclosporin O: Exploring the Utility of Bsmoc-NMe- Amino Acid Fluorides and KOAt

Volume: 16 Issue: 3

Author(s): Vommina Venkata Sureshbabu, Subramanyam J. Tantry, Gundala Chennakrishnareddy and Govindappa Nagendra

Affiliation:

Keywords: Cyclosporin O, Acid fluoride, KOAt, N-Methyl amino acid, Diethyl amine

Abstract: Cyclosporin O (CyO), an immunosuppressent cyclic undecapeptide, was synthesized by convergent approach employing Bsmoc-Nmethyl amino acid fluorides and Potassium Salt of 7-Aza-1-hydroxybenzotriazole (KOAt) in solution by stepwise assembly. The couplings were found to be epimerisation free. The difficulty in the coupling of four consecutive N-methyl amino acids at position 8, 9, 10 and 11 was overcome by repeating the coupling thrice at these critical positions. All the ten protected peptide fragments of CyO starting from the dipeptide to the undecapeptide and final protected as well as CyO were isolated and fully characterized.

Cite this article as:

Sureshbabu Venkata Vommina, Tantry J. Subramanyam, Chennakrishnareddy Gundala and Nagendra Govindappa, Total Synthesis of Cyclosporin O: Exploring the Utility of Bsmoc-NMe- Amino Acid Fluorides and KOAt, Protein & Peptide Letters 2009; 16 (3) . https://dx.doi.org/10.2174/092986609787601813